491842-63-8

Basic information

• Product Name: 3-(CHLOROMETHYL)-5-(3-FLUOROPHENYL)-1,2,4-OXADIAZOLE
• Synonyms: 3-(CHLOROMETHYL)-5-(3-FLUOROPHENYL)-1,2,4-OXADIAZOLE;1,2,4-Oxadiazole, 3-(chloroMethyl)-5-(3-fluorophenyl)-
• CAS NO: 491842-63-8
• Molecular Formula: C₉H₆ClFN₂O
• Molecular Weight: 212.6081432
• Mol File: 491842-63-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 321.778 °C at 760 mmHg
• Flash Point: 148.406 °C
• Appearance: /
• Density: 1.364 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(CHLOROMETHYL)-5-(3-FLUOROPHENYL)-1,2,4-OXADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(CHLOROMETHYL)-5-(3-FLUOROPHENYL)-1,2,4-OXADIAZOLE(491842-63-8)
• EPA Substance Registry System: 3-(CHLOROMETHYL)-5-(3-FLUOROPHENYL)-1,2,4-OXADIAZOLE(491842-63-8)

Safety Data

• Hazardous Substances Data: 491842-63-8(Hazardous Substances Data)

Usage

General Description

3-(Chloromethyl)-5-(3-fluorophenyl)-1,2,4-oxadiazole is a chemical compound that belongs to the oxadiazole class of compounds. It is a heterocyclic compound containing oxygen, nitrogen, and chlorine atoms in its structure. 3-(Chloromethyl)-5-(3-fluorophenyl)-1,2,4-oxadiazole has potential applications in various fields including pharmaceuticals, agrochemicals, and materials science. Its unique structural features make it a valuable building block for the development of novel drugs, pesticides, and functional materials. 3-(Chloromethyl)-5-(3-fluorophenyl)-1,2,4-oxadiazole has attracted attention from researchers due to its interesting biological and chemical properties, and it continues to be studied for its potential uses in different industries.

InChI:InChI=1/C9H6ClFN2O/c10-5-8-12-9(14-13-8)6-2-1-3-7(11)4-6/h1-4H,5H2

Upstream product

• 844498-87-9 C₉H₈ClFN₂O₂ 
• 3272-96-6 2-chloro-N-hydroxyethanimidamide 
• 1711-07-5 3-fluorobenzoyl chloride 
• 455-38-9 3-fluorobenzoic acid 
• 3272-96-6 2-chloro-N'-hydroxyacetimidamide 
• 3272-96-6 (Z)-2-chloro-N'-hydroxyethanimidamide 
• 844498-87-9 C₉H₈ClFN₂O₂ 

Downstream Products

• 1352565-37-7 (3R)-1-((5-(3-fluorophenyl)-1,2,4-oxadiazol-3-yl)methyl)-3-(2-(3-fluorophenylamino)-2-phenylacetoxy)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate 
• 1055052-33-9 3-(4-{[5-(3-fluorophenyl)(1,2,4-oxadiazol-3-yl)]methyl}piperazinyl)-1-(2-methylbenzothiazol-5-yloxy)propan-2-ol 

Relevant articles and documents

ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF

The present invention relates to alkaloid aminoester derivatives acting as muscarinic receptor antagonists, processes for their preparation, compositions comprising them and therapeutic uses thereof.

The discovery of a selective, high affinity A2B adenosine receptor antagonist for the potential treatment of asthma

Adenosine has been suggested to play a role in asthma, possibly via activation of A2B adenosine receptors on mast cells and other pulmonary cells. We describe our initial efforts to discover a xanthine based selective A2B AdoR antagonist that resulted in the discovery of CVT-5440, a high affinity A2B AdoR antagonist with good selectivity (A2B AdoR Ki = 50 nM, selectivity A1 > 200: A2A > 200: A3 > 167).

NEW COMPOUNDS

The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4, R, R1, R2, R3, R4, R5, R6, R7, m, n, o, p and q are defined as in any one of claims 1 to 12, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.