491872-95-8Relevant academic research and scientific papers
Synthesis of triazolyl-oxadiazolyl-thiazolyl- and thiadiazolylbenzofuran of potential biological activity
Atta,Fawzy,Ahmed,Abdel-Rahman
, p. 863 - 875 (2007/10/03)
4,7-Dimethoxy (Ia) and 4-methoxy (Ib) 6-hydroxybenzofuran-5-carbohydrazide were reacted with aryl or alkyl isothiocyanates to give the corresponding thiosemicarbazides (IIa-h). Cyclization of the substituted thiosemicarbazides with sodium hydroxide led to the formation of 1,3,4-triazol-2-yl-benzofuran derivatives (IIIa-d). Desulfurization of thiosemicarbazide by mercuric oxide gave 1,3,4-oxadiazolyl-benzofuran (IVa-c). Treatment of thiosemicarbazide with ethyl bromo-acetate or α-bromopropionic acid yielded 4-thiazolidin-2-yl-carbonyl-benzofuran (Va-h). The reaction of compounds IIb,e,f with sulphuric acid or phosphorus oxychloride gave 1,3,4-thiadiazol-2-yl-benzofuran (VIa-d, VII).
