491878-06-9 Usage
General Description
ACS-PNZ-PYRROLIDYL-(BOC)-NSO2NH2 is a chemical compound that belongs to the class of pyrrolidine derivatives. It is commonly used in organic synthesis and medicinal chemistry as a building block for the preparation of various pharmaceutical compounds. The compound contains a pyrrolidyl group, which is a five-membered ring containing four carbon atoms and one nitrogen atom. The presence of the BOC (tert-butoxycarbonyl) protecting group on the pyrrolidyl nitrogen atom makes the compound suitable for use in organic synthesis reactions. The NSO2NH2 group in the compound implies the presence of a sulfonyl group, which is a common functional group found in many organic compounds. Overall, ACS-PNZ-PYRROLIDYL-(BOC)-NSO2NH2 plays an essential role as a versatile chemical building block in various fields of chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 491878-06-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,1,8,7 and 8 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 491878-06:
(8*4)+(7*9)+(6*1)+(5*8)+(4*7)+(3*8)+(2*0)+(1*6)=199
199 % 10 = 9
So 491878-06-9 is a valid CAS Registry Number.
InChI:InChI=1/C20H28N4O9S2/c1-13(25)34-17-9-16(10-23(35(21,30)31)19(27)33-20(2,3)4)22(11-17)18(26)32-12-14-5-7-15(8-6-14)24(28)29/h5-8,16-17H,9-12H2,1-4H3,(H2,21,30,31)/t16-,17-/m0/s1
491878-06-9Relevant articles and documents
Practical large-scale synthesis of the 2-aminomethylpyrrolidin-4-ylthio-containing side chain of the novel carbapenem antibiotic doripenem
Nishino, Yutaka,Komurasaki, Tadafumi,Yuasa, Tetsuya,Kakinuma, Makoto,Izumi, Kenji,Kobayashi, Makoto,Fujiie, Shinichiro,Gotoh, Teruhiro,Masui, Yoshiyuki,Hajima, Makoto,Takahira, Masayuki,Okuyama, Akira,Kataoka, Takahiro
, p. 649 - 654 (2013/09/05)
The first synthesis using an original procedure and a practical large-scale process using an improved procedure for the synthesis of the N-PNZ-protected 2-aminomethylpyrrolidin-4-ylthio-containing side chain of doripenem hydrate (S-4661), a novel parenteral 1β-methylcarbapenem antibiotic, are described, trans-4-Hydroxy-L-proline (4) was converted in an efficient process to (2S,4S)-4-acetylthio-2-(N-sulfamoyl-tert-butoxycarbonylaminomethyl) -1-(4-nitrobenzyloxycarbonyl)pyrrolidine (3) in 55-56% overall yield via a six-step sequence, which includes the two alternative routes to intermediate 13. This process requires no chromatographic purifications, no cryogenic temperatures, no haloalkane solvents, and short operating times and is amenable to a multikilogram-scale preparation. Several kilograms of the side chain 3 were successfully prepared by this process.
