4923-63-1

Basic information

• Product Name: 2-Piperidino-1, 4-naphthoquinone
• Synonyms: 1,4-Naphthalenedione, 2- (1-piperidinyl)-
• CAS NO: 4923-63-1
• Molecular Formula: C15H15NO2
• Molecular Weight: 241.2851
• Mol File: 4923-63-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 394.4°Cat760mmHg
• Flash Point: 177.2°C
• Appearance: /
• Density: 1.258g/cm³
• Vapor Pressure: 1.99E-06mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: 2-Piperidino-1, 4-naphthoquinone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperidino-1, 4-naphthoquinone(4923-63-1)
• EPA Substance Registry System: 2-Piperidino-1, 4-naphthoquinone(4923-63-1)

Safety Data

• Hazardous Substances Data: 4923-63-1(Hazardous Substances Data)

Usage

General Description

2-Piperidino-1, 4-naphthoquinone, also known as PNQ, is a chemical compound with a distinctive structure that includes a piperidine ring attached to a naphthoquinone core. It is a synthetic derivative of vitamin K and has been studied for its potential uses in medicine and chemistry. PNQ has been found to have anti-tumor and anti-cancer properties, showing potential as a cytotoxic agent against various cancer cell lines. Additionally, it has demonstrated reactivity with nucleophilic and electrophilic substrates, making it a versatile compound for use in organic synthesis. Further research into the potential medical and chemical applications of PNQ is ongoing, and it continues to be an area of interest in the scientific community.

InChI:InChI=1/C15H15NO2/c17-14-10-13(16-8-4-1-5-9-16)15(18)12-7-3-2-6-11(12)14/h2-3,6-7,10H,1,4-5,8-9H2

Upstream product

• 110-89-4 piperidine 
• 130-15-4 [1,4]naphthoquinone 
• 2213-43-6 1-Aminopiperidine 
• 58-27-5 menadione 

Relevant articles and documents

Gold(III)-catalyzed 1,4-nucleophilic addition: Facile approach to prepare 2-amino-1,4-naphthalenedione and 6-amino-5,8-quinolinedione derivatives

An efficient approach is developed to prepare different 2-amino-1,4-naphthalenedione and 6-amino-5,8-quinolinedione derivatives regioselectively by Au(III)-catalyzed 1,4-nucleophilic addition and subsequent oxidation. A wide variety of primary, secondary, and aromatic amines, as well as allylamine and 2-butynylamine are well tolerated under the mild conditions to give products in moderate to good yields. Georg Thieme Verlag Stuttgart.

Synthesis and pharmacological studies of some 2-t-amino and 2,3-di-t-amino substituted 1,4-naphthoquinones and related compounds

Series of 2-t-amino and 2,3-di-t-amino substituted -1,4-naphthoquinones have been synthesised from corresponding 1,4-naphthoquinones by reaction with secondary amines. The compounds have been evaluated for their broad spectrum antimicrobial, antiviral and

Photo-oxidation of 2-methylamino-3-(1-piperidinylmethyl)-1,4-naphthoquinone

2-Methylamino-3-(1-piperidinylmethyl)-1,4 (7) was prepared via several steps from 2-methyl-1,4-naphthoquinone (vitamin K3 3). The quinone (7) was photochemically oxidized to 2-methylamino-3-(1-piperidinylcarbonyl)-1,3-naphthoquinone (8) and/or 2-alkoxycarbonyl-3-methylamino-1,4-naphthoquinone (9), depending on the solvent used.