492456-57-2

Basic information

• Product Name: 3-Quinolinecarbonitrile, 4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-(trifluoromethoxy)-
• CAS NO: 492456-57-2
• Molecular Formula: C17H7ClF4N4O3
• Molecular Weight: 426.714
• Mol File: 492456-57-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-Quinolinecarbonitrile, 4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-(trifluoromethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarbonitrile, 4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-(trifluoromethoxy)-(492456-57-2)
• EPA Substance Registry System: 3-Quinolinecarbonitrile, 4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-(trifluoromethoxy)-(492456-57-2)

Safety Data

• Hazardous Substances Data: 492456-57-2(Hazardous Substances Data)

Upstream product

• 492456-53-8 4-hydroxy-7-(trifluoromethoxy)quinoline-3-carbonitrile 
• 1535-73-5 m-trifluoromethoxyaniline 
• 492456-54-9 4-hydroxy-6-nitro-7-trifluoromethoxyquinoline-3-carbonitrile 
• 2267-21-2 2-trifluoromethoxy-4-aminonitrobenzene 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 492456-55-0 4-chloro-6-nitro-7-trifluoromethoxyquinoline-3-carbonitrile 

Downstream Products

• 492456-58-3 6-amino-4-(3-chloro-4-fluorophenylamino)-7-trifluoromethoxyquinoline-3-carbonitrile 

Relevant articles and documents

Inhibition of Tpl2 kinase and TNFα production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis

The synthesis and structure-activity studies of a series of quinoline-3-carbonitriles as inhibitors of Tpl2 kinase are described. Potent inhibitors of Tpl2 kinase with selectivity against a panel of selected kinases in enzymatic assays and specificity in cell-based phosphorylation assays in LPS-treated human monocytes were identified. Selected inhibitors with moderate activity in human whole blood assay effectively inhibited LPS/D-Gal induced TNFα release when administered intraperitoneally in mice.