492456-57-2Relevant academic research and scientific papers
Inhibition of Tpl2 kinase and TNFα production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis
Hu, Yonghan,Green, Neal,Gavrin, Lori K.,Janz, Kristin,Kaila, Neelu,Li, Huan-Qiu,Thomason, Jennifer R.,Cuozzo, John W.,Hall, J. Perry,Hsu, Sang,Nickerson-Nutter, Cheryl,Telliez, Jean-Baptiste,Lin, Lih-Ling,Tam, Steve
, p. 6067 - 6072 (2007/10/03)
The synthesis and structure-activity studies of a series of quinoline-3-carbonitriles as inhibitors of Tpl2 kinase are described. Potent inhibitors of Tpl2 kinase with selectivity against a panel of selected kinases in enzymatic assays and specificity in cell-based phosphorylation assays in LPS-treated human monocytes were identified. Selected inhibitors with moderate activity in human whole blood assay effectively inhibited LPS/D-Gal induced TNFα release when administered intraperitoneally in mice.
Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epi
Wissner, Allan,Overbeek, Elsebe,Reich, Marvin F.,Floyd, M. Brawner,Johnson, Bernard D.,Mamuya, Nellie,Rosfjord, Edward C.,Discafani, Carolyn,Davis, Rachel,Shi, Xiaoqing,Rabindran, Sridhar K.,Gruber, Brian C.,Ye, Fei,Hallett, William A.,Nilakantan, Ramaswamy,Shen, Ru,Wang, Yu-Fen,Greenberger, Lee M.,Tsou, Hwei-Ru
, p. 49 - 63 (2007/10/03)
A series of of 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile derivatives that function as irreversible inhibitors of EGFR and HER-2 kinases have been prepared. These inhibitors have, at the 6-position, butynamide, crotonamide, and methacrylamide Mic
