492464-46-7

Upstream product

• 72-18-4 L-valine 
• 91425-31-9 2-(triphenylmethylthio)ethanoic acid-N-hydroxysuccinimido ester 
• 76-83-5 trityl chloride 
• 34914-36-8 2-(triphenylmethylthio)ethanoic acid 

Downstream Products

• 492464-47-8 (S)-3-Methyl-2-(2-tritylsulfanyl-acetylamino)-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 1345965-29-8 C₃₆H₃₇N₇O₂S 
• 886439-43-6 N-[[(triphenylmethyl)thio]acetyl]-L-valylglycyl-L-glutamine 
• 586351-17-9 N-[(cyclohexylcarbamoylmethyl-carbamoyl)-methyl]-3-methyl-2-(2-tritylsulfanyl-acetylamino)-butyramide 
• 586351-16-8 N-[(butylcarbamoylmethyl-carbamoyl)-methyl]-3-methyl-2-(2-tritylsulfanyl-acetylamino)-butyramide 
• 548485-18-3 {2-[(S)-3-Methyl-2-(2-tritylsulfanyl-acetylamino)-butyrylamino]-acetylamino}-acetic acid 
• 572914-86-4 N-(2-diethylamino-ethyl)-3-methyl-2-(2-tritylsulfanyl-acetylamino)-butyramide 
• 492464-48-9 N-(2-dimethylamino-ethyl)-3-methyl-2-(2-tritylsulfanyl-acetylamino)-butyramide 

Relevant academic research and scientific papers

Preparation and bioevaluation of 99mTc nitrido radiopharmaceuticals with pyrazolo[1,5-a]pyrimidine as tumor imaging agents

The 7-(2-aminoethylamino)-5-methyl-3-cyanopyrazolo[ 1,5-a]pyrimidine (AMCPP) was synthesized and conjugated with N-mercaptoacetylglycine (MAG), N-mercaptoacetylphenylalanine (MAF), and N-mercaptoacetylvaline (MAA), respectively. These three compounds were labeled successfully with [ 99mTcN]2+ intermediate in high radiochemical purities. Biodistribution in tumor-bearing mice demonstrated that the three new complexes showed high tumor-to-muscle (T/M) ratios and rapid clearance from the blood, muscle, liver, kidney, and lung. Among them, the 99mTcN-MAG-AMCPP showed the most favorable characteristics. The tumor/blood and tumor/muscle ratios reached 1.50 and 1.15 at 30 min post-injection, 2.20 and 1.83 at 60 min post-injection. Springer Science+Business Media, LLC 2011.

Synthesis, biodistribution and qsar studies of five Tc-99M labeled novel N3S pseudo-peptide complexes

Five novel N3S pseudo-peptide chelators derived from mercaptoacetic acid have been synthesized and characterized based on the spectroscopic data. All the chelators were labeled with Technicium-99m to evaluate their biological activities. Invest

Synthesis and characterization of novel N3S chelators and biodistribution of their 99Tcm labeled complexes as potential kidney imaging agents

Two new target chelators were synthesized through five steps with mercaptoacetic acid as the primary material, and identified by spectroscopy data including IR, 1HNMR, 13CNMR, Ms as new kidney imaging agents. The chelators were label

Synthesis of novel N3S pseudo-peptide and biodistribution of 99Tcm-pseudo-peptide complexes in mice

An excellent reaction condition of active ester with amine acid was developed, and a series of novel N3S pseudo-peptide chelators starting from mercaptoacetic acid were synthesized and characterized based on the spectroscopic data, such as IR,