492468-13-0Relevant articles and documents
ASYMMETRIC CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS WITH DIAZO REAGENTS
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Page/Page column 9; 11-12, (2010/04/23)
Cobalt-catalyzed asymmetric cyclopropanation of electron-deficient olefins.
Cobalt-catalyzed asymmetric cyclopropanation of electron-deficient olefins
Chen, Ying,Ruppel, Joshua V.,Zhang, X. Peter
, p. 12074 - 12075 (2008/03/27)
The cobalt(II) complex of a D2-symmetric chiral porphyrin [Co(1)] is an effective catalyst for asymmetric cyclopropanation of electron-deficient olefins, including α,β-unsaturated esters, amides, ketones, and nitriles. Due to the absence of dimerization of diazo compounds, the catalytic reactions can be performed in one-pot protocol using olefins as the limiting reagent, forming the desired electrophilic cyclopropane derivatives in high yields and selectivities under mild conditions. In most cases, both excellent diastereo- and enantioselectivity were achieved. Copyright
