492472-01-2Relevant academic research and scientific papers
Complexes of cyclic polyaza chelators with cations of alkaline earth metals for enhanced biological activity
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Page/Page column 12, (2010/02/11)
Cyclic polyaza chelators that possess high affinity and specificity for first transition series metal cations exhibit an unanticipated improvement in biological activity when administered as complexes with cations of the alkaline earth metals, Ca(II) and Mg(II), most notably Ca(II). By virtue of this improvement, these complexes are particularly effective in the treatment of pathological conditions, including ischemia and ischemia-reperfusion injury.
2-pyrrolidone derivatives as prostanoid agonists
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, (2008/06/13)
This invention relates to 8-aza prostanoid analogs which are generally EP4 receptor agonists and are represented by Formula I: wherein Q, B, X, J, Z, A and R1-R6 are as defined, their synthesis and use for treatment of osteoporosis and increasing bone density.
