4928-44-3

Basic information

• Product Name: N~2~-phenylpyridine-2,5-diamine
• Synonyms: N~2~-phenylpyridine-2,5-diamine;AKOS BBV-006853;OTAVA-BB 1119566;UKRORGSYN-BB BBV-006853;N~2~-phenylpyridine-2,5-diamine(SALTDATA: FREE)
• CAS NO: 4928-44-3
• Molecular Formula: C₁₁H₁₁N₃
• Molecular Weight: 185.229
• Mol File: 4928-44-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 379.8°C at 760 mmHg
• Flash Point: 183.5°C
• Appearance: /
• Density: 1.226g/cm³
• Vapor Pressure: 5.71E-06mmHg at 25°C
• Refractive Index: 1.693
• CAS DataBase Reference: N~2~-phenylpyridine-2,5-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N~2~-phenylpyridine-2,5-diamine(4928-44-3)
• EPA Substance Registry System: N~2~-phenylpyridine-2,5-diamine(4928-44-3)

Safety Data

• Hazardous Substances Data: 4928-44-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H11N3/c12-9-6-7-11(13-8-9)14-10-4-2-1-3-5-10/h1-8H,12H2,(H,13,14)

Upstream product

• 64-17-5 ethanol 
• 6825-25-8 5-nitro-N-phenylpyridin-2-amine 
• 4487-59-6 2-bromo-5-nitropyridine 
• 62-53-3 aniline 
• 4548-45-2 2-chloro-5-nitropyridine 

Relevant articles and documents

Efficient and selective synthesis of alkoxy substituted di(pyridin-2-yl)amines and N-arylpyridin-2-ylamines

The formation of alkoxy substituted di(pyridin-2-yl)amines and N-arylpyridin-2-ylamines by nitro group reduction is described. Unexpected substitution of ortho with the amino at C-6 was observed during the reduction using SnCl2·2H2O

Novel potassium channel openers: Synthesis and pharmacological evaluation of new N-(substituted-3-pyridyl)-N'-alkylthioureas and related compounds

This report describes the synthesis and pharmacological evaluation of a series of novel potassium channel openers related to the pinacidil-type compounds. Thioureas, cyanoguanidines, and pyridine N-oxides were systematically evaluated for their effects on both the inhibition of spontaneous mechanical activity in rat portal vein (in vitro) and their antihypertensive activity (in vivo), and the structure-activity relationship for this series of compounds was discussed. Good correlation between in vitro and iv antihypertensive activity was observed for these compounds. Among them, cyanoguanidines bearing a conformationally rigid unit such as a norbornyl group generally possessed potent activity in both in vitro and in vivo studies. Especially, N-(6-amino-3-pyridyl)-N'-cyano-N''-(1-methyl-2- norbornyl)guanidine (23d) was identified as a more potent potassium channel opener in vitro (EC100 = 3 x 10-8 M) than pinacidil (EC100 = 10-7 M).