493-47-0

Usage

Uses

Used in Pharmaceutical Industry:
Lichesterinic acid is used as a potential therapeutic agent for its anti-inflammatory, antimicrobial, and antioxidant properties. Its ability to inhibit the release of inflammatory mediators contributes to its hepatoprotective effects, making it a candidate for liver disease treatment.
Used in Cancer Therapy:
Lichesterinic acid is used as a potential anticancer agent due to its cytotoxic effects against cancer cells. It may be employed in the development of novel cancer therapies, targeting various types of malignancies.
Used in Drug Development:
Lichesterinic acid's diverse biological activities and potential pharmacological properties make lichesterinic acid a promising target for drug development. Further research is needed to explore its full potential and optimize its therapeutic applications.

Upstream product

• 22800-25-5 (-)-lichesterinic acid 
• 70579-62-3 (+)-lichesterinic acid 
• 50-00-0 formaldehyd 
• 67910-85-4 methyl 4-methyl-5(2H)-oxo-2-tridecyl-furan-3-carboxylate 
• 493-46-9 (+)-protolichesterinic acid 
• 22800-27-7 (-)-allo-protolichesterinic acid 

Downstream Products

• 5703-13-9 2-methyl-3-tetradecyl-succinic acid 
• 171917-63-8 2-methyl-3-tetradecyl-succinic acid-anhydride 
• 29595-87-7 (+/-)-Lichesterylsaeure 

Relevant academic research and scientific papers

General approach to 2,4-dialkyl-3-carboxybutyrolactones: An efficient synthesis of (±)-striatisporolide A and (±)-lichesterinic acid

Starting from 2-alkylidene-3-methylsuccinimides, simple and efficient synthesis of the natural products striatisporolide A, lichesterinic acid and lichesterylic acid have been demonstrated via an acid catalyzed hydrolysis, esterification, OsO4- dihydroxylation and dehydrative cyclization pathway.

Vicinal dianion of triethyl ethanetricarboxylate: Syntheses of (±)-lichesterinic acid, (±)-phaseolinic acid, (±)-nephromopsinic acid, (±)-rocellaric acid, and (±)-dihydroprotolichesterinic acid

The vicinal dianion 2 derived from triethyl ethanetricarboxylate reacted regioselectively with aldehydes and ketones at C(β) to provide paraconic acid derivatives 5a-f in moderate to high yields as mixtures of diastereoisomers. The paraconic acid derivatives 5e and 5f were utilized as the starting materials for the syntheses of (±)-lichesterinic acid (12), (±)-phaseolinic acid (13), (±)-nephromopsinic acid (14), (±)-rocellaric acid (15), and (±)-dihydroprotolichesterinic acid (16).