493-47-0

Basic information

• Product Name: Lichesterinic acid
• CAS NO: 493-47-0
• Molecular Formula: C₁₉H₃₂O₄
• Molecular Weight: 324.461
• Mol File: 493-47-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 469.5°Cat760mmHg
• Flash Point: 158.7°C
• Density: 1.023g/cm³
• CAS DataBase Reference: Lichesterinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Lichesterinic acid(493-47-0)
• EPA Substance Registry System: Lichesterinic acid(493-47-0)

Safety Data

• Hazardous Substances Data: 493-47-0(Hazardous Substances Data)

Usage

General Description

Lichesterinic acid is a triterpenoid compound found in various plants and fungi, including Licania michauxii and Lichen sp. It is known for its potential pharmacological activities, including anti-inflammatory, antimicrobial, and antioxidant properties. Studies have shown that lichesterinic acid exhibits cytotoxic effects against cancer cells, making it a potential candidate for cancer therapy. Additionally, it has been reported to have hepatoprotective effects, possibly due to its ability to inhibit the release of inflammatory mediators. The compound's diverse biological activities make it a promising target for further research and potential drug development.

Upstream product

• 50-00-0 formaldehyd 
• 67910-85-4 methyl 4-methyl-5(2H)-oxo-2-tridecyl-furan-3-carboxylate 
• 22800-25-5 (-)-lichesterinic acid 
• 70579-62-3 (+)-lichesterinic acid 
• 493-46-9 (+)-protolichesterinic acid 
• 22800-27-7 (-)-allo-protolichesterinic acid 

Downstream Products

• 5703-13-9 2-methyl-3-tetradecyl-succinic acid 
• 29595-87-7 (+/-)-Lichesterylsaeure 
• 171917-63-8 2-methyl-3-tetradecyl-succinic acid-anhydride 

Relevant articles and documents

Biosynthesis of (plus)-protolichesterinic acid in Cetraria islandica.

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Vicinal dianion of triethyl ethanetricarboxylate: Syntheses of (±)-lichesterinic acid, (±)-phaseolinic acid, (±)-nephromopsinic acid, (±)-rocellaric acid, and (±)-dihydroprotolichesterinic acid

The vicinal dianion 2 derived from triethyl ethanetricarboxylate reacted regioselectively with aldehydes and ketones at C(β) to provide paraconic acid derivatives 5a-f in moderate to high yields as mixtures of diastereoisomers. The paraconic acid derivatives 5e and 5f were utilized as the starting materials for the syntheses of (±)-lichesterinic acid (12), (±)-phaseolinic acid (13), (±)-nephromopsinic acid (14), (±)-rocellaric acid (15), and (±)-dihydroprotolichesterinic acid (16).