493009-89-5Relevant articles and documents
Palladium(II)-catalyzed intramolecular hydroamination of 1,3-dienes to give homoallylic amines
Pierson, Justin M.,Ingalls, Erica L.,Vo, Richard D.,Michael, Forrest E.
supporting information, p. 13311 - 13313 (2014/01/06)
A pincer for high selectivity: A mild palladium-catalyzed hydroamination of protected amino-1,3-dienes is possible. This highly regioselective reaction employs a tridentate PNP pincer ligand and leads to cyclic and homoallylic protected amines in high yields. Substrates with a wide array of amine protecting groups and diene substitution patterns were cyclized to form five- and six-membered heterocycles. PG=protecting group.
High regioselectivity in electrochemical α-methoxylation of N-protected cyclic amines
Libendi, Samuel S.,Demizu, Yosuke,Matsumura, Yoshihiro,Onomura, Osamu
, p. 3935 - 3942 (2008/09/20)
N-Protecting groups of α-substituted cyclic amines strongly affected the regioselectivity in electrochemical methoxylation of these compounds. Namely, N-acyl derivatives were transformed into α′-methoxylated compounds, while N-cyano derivatives changed into α-methoxylated derivatives. Furthermore, Lewis acid catalyzed nucleophilic substitution of the α-methoxylated compounds protected with cyano group afforded α,α-disubstituted cyclic amines.
