493036-50-3

Basic information

• Product Name: 2-(4-TRIFLUOROMETHYLPHENYL)MALONDIALDEHYDE
• Synonyms: 2-[4-(TRIFLUOROMETHYL)PHENYL]MALONALDEHYDE;2-(4-TRIFLUOROMETHYLPHENYL)MALONDIALDEHYDE;4-(TRIFLUOROMETHYLPHENYL)MALONDIALDEHYDE;2-(4-TRIFLUOROMETHYLPHENYL)MALONDIALDEHYDE 97%;[4-(Trifluoromethyl)phenyl]propane-1,3-dial
• CAS NO: 493036-50-3
• Molecular Formula: C10H7F3O2
• Molecular Weight: 216.16
• EINECS: 942-837-2
• Mol File: 493036-50-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 132-134°C
• Boiling Point: 299.5°C at 760 mmHg
• Flash Point: 135°C
• Appearance: /
• Density: 1.333g/cm³
• Vapor Pressure: 0.000529mmHg at 25°C
• Refractive Index: 1.497
• CAS DataBase Reference: 2-(4-TRIFLUOROMETHYLPHENYL)MALONDIALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-TRIFLUOROMETHYLPHENYL)MALONDIALDEHYDE(493036-50-3)
• EPA Substance Registry System: 2-(4-TRIFLUOROMETHYLPHENYL)MALONDIALDEHYDE(493036-50-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 493036-50-3(Hazardous Substances Data)

Usage

General Description

2-(4-trifluoromethylphenyl)malondialdehyde is a chemical compound with the molecular formula C10H6F3NO2. It is a malondialdehyde derivative with a trifluoromethyl group attached to the phenyl ring. 2-(4-TRIFLUOROMETHYLPHENYL)MALONDIALDEHYDE is commonly used as a reagent in organic synthesis reactions and is also known for its potential use as a fluorescent sensor for detecting lipid peroxidation in biological systems. Additionally, it has been studied for its potential pharmacological properties, including its antioxidant and anti-inflammatory effects. Its unique structure and properties make it a valuable compound for research in various scientific fields.

InChI:InChI=1/C10H7F3O2/c11-10(12,13)9-3-1-7(2-4-9)8(5-14)6-15/h1-6,14H/b8-5-

Upstream product

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Relevant articles and documents

ER-Targeting Cyanine Dye as an NIR Photoinducer to Efficiently Trigger Photoimmunogenic Cancer Cell Death

Endoplasmic reticulum (ER) stress, caused by overproduction of reactive oxygen species (ROS), has been shown to be responsible for immunogenic cell death (ICD). Seeking ROS generator targeting ER is an optimal solution to efficiently induce ER stress. Despite clear indications of demand for ER-targeting photosensitizer, the alternative chemical tools remain limited. Herein, the first ER-localizable ICD photoinducer using thio-pentamethine cyanine dye (TCy5) to induce ER stress under mild near-infrared (NIR) irradiation has been developed. Within the ICD photoinducer design, polyfluorinated TCy5-Ph-3F possesses a selective tropism to ER accumulation and superior ROS generation capability in both normoxia and hypoxia conditions, which benefit from its low singlet-triplet gaps. Under NIR irradiation, cancer cells stained by TCy5-Ph-3F will lead to ER stress and induce massive emission of damage-associated molecular patterns, including calreticulin and heat-shock protein 70 exposure, high mobility group box 1 efflux, and adenosine triphosphate secretion. Dendritic cells maturation and CD8+T cells activation in vivo also highlight the effectiveness. Therefore, the growth of abscopal tumors was substantially suppressed by the primary tumor treated with TCy5-Ph-3F and NIR irradiation. These results confer practical applicability that could provide a guideline for designing efficient ICD photoinducers, which will enable expanding organic molecular applications for cancer immunotherapy.

Synthesis, anticancer activity and DNA-binding properties of novel 4-pyrazolyl-1,8-naphthalimide derivatives

A novel series of 4-pyrazolyl-1,8-naphthalimide derivatives have been designed and facilely synthesized. For anticancer activity in vitro, most of the compounds were found to be more toxic against human mammary cancer cells (MCF-7) than human cervical car