4939-81-5Relevant academic research and scientific papers
METHOD AND MEANS FOR MANUFACTURING TERPENE INDOLE ALKALOIDS
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Page/Page column 36, (2019/10/04)
The complex chemistry underlying the extensive transformations involved in terpene indole alkaloid synthesis makes identification of the biosynthetic genes challenging. The present invention relates to methods for producing a terpene indole alkaloid derivative, comprising the steps of: (1) providing a terpene indole alkaloid; and (2) providing a first enzyme termed "Precondylocarpine Acetate Synthase" (PAS) or a functional variant or homologue thereof; and/or a second enzyme termed "Dehydroprecondylocarpine Acetate Synthase" (DPAS) or a functional variant or homologue thereof, and optionally providing further identified enzymes involved in this pathway. The invention also encompasses related kits, enzymes, expression vectors, host cells and plants.
Total synthesis of (+)-condylocarpine, (+)-isocondylocarpine, and (+)-tubotaiwine
Martin, Connor L.,Nakamura, Seiichi,Otte, Ralf,Overman, Larry E.
supporting information; experimental part, p. 138 - 141 (2011/03/19)
The first enantioselective total syntheses of indole alkaloids of the condylocarpine type are reported. (+)-Condylocarpine, (+)-isocondylocarpine, and (+)-tubotaiwine were prepared in high enantiomeric purity (er > 99:1) from (1S,5R)-hexahydro-1,5-methano-1H-azocino[4,3-b]indole-12-one 7b by way of five or six isolated intermediates.
