494198-41-3Relevant academic research and scientific papers
Pyrano[3,4-c]quinolines from 1-desaza-1-oxa-nifedipine
Goerlitzer, Klaus,Trittmacher,Jones,Frohberg,Drutkowski
, p. 539 - 542 (2007/10/03)
The reaction of the 1,5-diketone 1 with acetic anhydride/acetic acid in the presence of zinc chloride yields the 1-desaza-1-oxa-nifedipine 2 and the annulated lactone 3 as a by-product. The structures of 2 and 3 are confirmed by X-ray structure analysis. The pH-dependent reduction of the nitro group from 2 leads to the pyrano[3,4-c]quinolines 4Aa, b by ring closure. The cyclic hydroxamic acid 4Aa represents a weak, non-selective inhibitor of 5-, 12- and 15-lipoxygenase of human full-blood.
