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2-morpholin-4-yl-ethanesulfonic acid amide, also known as MES, is a zwitterionic buffering agent commonly used in biological and chemical research. It is a white crystalline powder with a molecular formula of C6H13NO4S and a molecular weight of 191.24 g/mol. MES is soluble in water and has a pKa value of approximately 6.1, making it suitable for maintaining a stable pH in the range of 5.5 to 6.6. It is often used in place of other buffers like acetate or phosphate when a more neutral pH is required, particularly in enzyme assays, cell culture media, and electrophoresis. MES is also known for its ability to minimize protein precipitation and denaturation, which can be an issue with other buffers at low pH values.

4945-80-6

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4945-80-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4945-80-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,9,4 and 5 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4945-80:
(6*4)+(5*9)+(4*4)+(3*5)+(2*8)+(1*0)=116
116 % 10 = 6
So 4945-80-6 is a valid CAS Registry Number.

4945-80-6Downstream Products

4945-80-6Relevant academic research and scientific papers

β-(Cycloalkylamino)ethanesulfonyl azides as novel water-soluble reagents for the synthesis of diazo compounds and heterocycles

Shafran, Yuri M.,Silaichev, Pavel S.,Bakulev, Vasiliy A.

, p. 1251 - 1261 (2020/01/11)

[Figure not available: see fulltext.] Novel water-soluble sulfonyl azides were synthesized, which are basic by nature. The obtained compounds were used as donors of the diazo group in the diazo transfer reaction. Due to their good solubility in water and high polarity, the byproducts formed in this case were easily separated from the desired products by washing with water or column chromatography. It was also shown that new sulfonyl azides as a result of reactions can be incorporated in heterocyclic products, imparting them water solubility.

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