494748-16-2Relevant academic research and scientific papers
A stereoselective inverting sec -alkylsulfatase for the deracemization of sec -alcohols
Schober, Markus,Gadler, Petra,Knaus, Tanja,Kayer, Heidemarie,Birner-Gruenberger, Ruth,Guelly, Christian,MacHeroux, Peter,Wagner, Ulrike,Faber, Kurt
supporting information; body text, p. 4296 - 4299 (2011/10/08)
A metallo-β-lactamase-type alkylsulfatase was found to catalyze the enantioselective hydrolysis of sec-alkylsulfates with strict inversion of configuration. This catalytic event, which does not have an analog in chemocatalysis, yields homochiral (S)-configurated alcohols and nonreacted sulfate esters. The latter could be converted into (S)-sec-alcohols as the sole product in up to >99% ee via a chemoenzymatic deracemization protocol on a preparative scale.
