494760-54-2

Upstream product

• 374638-50-3 3-((2R,4aR,5S,7S,8aR,9aS,10aR)-4a,10a-Dimethyl-2-phenyl-5-triisopropylsilanyloxy-octahydro-1,3,8,10-tetraoxa-anthracen-7-yl)-propan-1-ol 

Downstream Products

• 494760-57-5 (2R,3S,4aR,6S,8S,8aS)-8-Benzyloxy-6-(3-benzyloxy-propyl)-2-[1,3]dithian-2-ylmethyl-2,8a-dimethyl-octahydro-pyrano[3,2-b]pyran-3-ol 
• 378742-11-1 (2R,3S,4aR,6S,8S,8aS)-8-Benzyloxy-6-(3-benzyloxy-propyl)-2-hydroxymethyl-2,8a-dimethyl-octahydro-pyrano[3,2-b]pyran-3-ol 
• 494760-56-4 2-[(2R,3S,4aR,6S,8S,8aS)-8-Benzyloxy-6-(3-benzyloxy-propyl)-3-(tert-butyl-dimethyl-silanyloxy)-2,8a-dimethyl-octahydro-pyrano[3,2-b]pyran-2-yl]-ethanol 
• 378742-01-9 [(2R,3S,4aR,6S,8S,8aS)-8-Benzyloxy-6-(3-benzyloxy-propyl)-3-(tert-butyl-dimethyl-silanyloxy)-2,8a-dimethyl-octahydro-pyrano[3,2-b]pyran-2-yl]-methanol 
• 494760-55-3 [(2R,3S,4aR,6S,8S,8aS)-8-Benzyloxy-6-(3-benzyloxy-propyl)-3-(tert-butyl-dimethyl-silanyloxy)-2,8a-dimethyl-octahydro-pyrano[3,2-b]pyran-2-yl]-acetaldehyde 

Relevant academic research and scientific papers

Total synthesis of gambierol

The convergent total synthesis of gambierol (1) is described. The octacyclic ether framework of 1 was constructed via the intramolecular allylation of α-chloroacetoxy ether followed by ring-closing metathesis. A modified Stille coupling was successfully applied to the synthesis of the triene side chain. Copyright