494775-35-8

Upstream product

• 108-24-7 acetic anhydride 
• 98-59-9 p-toluenesulfonyl chloride 
• 639079-77-9 1-β-D-[2-O-acetyl-arabinofuranosyl]-2-nitroimidazole 
• 532-20-7 D-Ribose 
• 911144-04-2 1-β-[2',3'-di-O-acetyl-5'-O-(tert-butyldiphenylsilyl)-D-ribofuranosyl]-2-nitroimidazole 
• 1332879-92-1 tri-O-acetyl-5-O-(tert-butyldiphenylsilyl)-β-D-ribofuranose 
• 911144-06-4 1-β-[2',3'-di-O-acetyl-D-ribofuranosyl]-2-nitroimidazole 
• 67773-76-6 1-α-(2',3',5-tri-O-benzoyl-D-ribofuranosyl)-2-nitroimidazole 
• 1332880-01-9 1-α-[2',3'-di-O-acetyl-D-ribofuranosyl]-2-nitroimidazole 
• 1332880-00-8 1-α-[2',3'-di-O-acetyl-5'-O-(tert-butyldiphenylsilyl)-D-ribofuranosyl]-2-nitroimidazole 
• 1332879-98-7 1-α-[5'-O-(tert-butyldiphenylsilyl)-D-ribofuranosyl]-2-nitroimidazole 
• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 220792-98-3 1-α-(2',3'-di-O-acetyl-D-arabinofuranosyl)-2-nitroimidazole 
• 845868-93-1 1,2,3-tri-O-acetyl-5-O-t-butyldiphenylsilyl-D-arabinofuranose 

Relevant academic research and scientific papers

Preparation of nucleosides derived from 2-nitroimidazole and d -arabinose, d -ribose, and d -Galactose by the Vorbrueggen method and their conversion to potential precursors for tracers to image hypoxia

2-Nitroimidazole was silylated using hexaethyldisilazane and then reacted with 1-O-acetyl derivatives of d-arabinose, d-ribose, and d-galactose in acetonitrile at mild temperatures (-20 °C to rt), catalyzed by triethylsilyl triflate (Vorbrueggen condition

Novel compounds for hypoxic cell therapy and imaging

The present invention provides for compounds suitable for therapeutic treatment of hypoxic tissues, particularly for application in radiotherapy, chemosensitization, radiosensitization. The present invention further provides for compounds suitable for rad

NOVEL SUBSTITUTED 2-NITROIMIDAZOLES USEFUL FOR HYPOXIC CELL THERAPY AND IMAGING

The present invention provides for substituted 2-nitroimidazoles suitable for the therapeutic treatment of hypoxic tissues, particularly for application in radiotherapy, chemosensitization and radiosensitization The present invention further provides subs

Synthesis of 1-beta-D-(5-deoxy-5-iodoarabinofuranosyl)-2-nitroimidazole (beta-IAZA): a novel marker of tissue hypoxia.

The present work describes the synthesis of the beta-isomer of 1-alpha-D-(5-deoxy-5-iodoarabinofuranosyl)-2-nitroimidazole (IAZA). Radioiodinated IAZA ((123)I-IAZA) has been extensively studied as a radiopharmaceutical for the diagnosis of regional and/or