494784-04-2

Basic information

• Product Name: (S)-1-[3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl]-3-(5-hexyn-1-yl)uracil
• Synonyms: (S)-1-[3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl]-3-(5-hexyn-1-yl)uracil
• CAS NO: 494784-04-2
• Molecular Weight: 568.67
• Mol File: 494784-04-2.mol

Chemical Properties

• CAS DataBase Reference: (S)-1-[3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl]-3-(5-hexyn-1-yl)uracil(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-[3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl]-3-(5-hexyn-1-yl)uracil(494784-04-2)
• EPA Substance Registry System: (S)-1-[3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl]-3-(5-hexyn-1-yl)uracil(494784-04-2)

Safety Data

• Hazardous Substances Data: 494784-04-2(Hazardous Substances Data)

Upstream product

• 928-90-5 5-hexyl-1-ol 
• 55559-60-9 (S)-1-(2,3-O-isopropylidene-2,3-dihydroxypropyl)uracil 
• 494784-01-9 (S)-1-(2,3-O-isopropylidene-2,3-dihydroxypropyl)-3-benzoyluracil 
• 494784-02-0 (S)-1-(2,3-O-isopropylidene-2,3-dihydroxypropyl)-3-(5-hexyn-1-yl)uracil 

Downstream Products

• 494784-07-5 ({6-[(bis-methoxycarbonylmethyl-amino)-methyl]-4-[6-(3-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-hex-1-ynyl]-pyridin-2-ylmethyl}-methoxycarbonylmethyl-amino)-acetic acid methyl ester 

Relevant articles and documents

Oligonucleotide conjugates based on acyclonucleosides and their use in DNA hybridization assays

Synthesis of two oligonucleotide building blocks based on acyclonucleosides (10, 11) which enable the introduction of several nonluminescent and luminescent lanthanide(III) chelates to the oligonucleotide structure is described. They were used in an instrument-assisted DNA synthesis in a standard manner. A modified deprotection procedure was used to ensure metal complexation. Also the applicability of these oligonucleotide conjugates to DNA hybridization assays is demonstrated.