494796-54-2

Usage

Uses

Used in Pharmaceutical Industry:
(S)-3-(4-chlorophenyl)-2-hydroxypropionic acid is used as an analgesic for alleviating pain, as an antipyretic to reduce fever, and as an anti-inflammatory agent to decrease inflammation. Its application is primarily due to its effectiveness in treating conditions such as arthritis, menstrual cramps, and minor injuries.
Used in Over-the-Counter Medicines:
(S)-3-(4-chlorophenyl)-2-hydroxypropionic acid is used as an active ingredient in over-the-counter (OTC) medications for its accessibility and general safety when used as directed. This allows individuals to manage mild to moderate pain and inflammation without a prescription.
Used in Treatment of Specific Conditions:
In the medical field, (S)-3-(4-chlorophenyl)-2-hydroxypropionic acid is used as a therapeutic agent for specific conditions like arthritis and menstrual cramps, where its anti-inflammatory and analgesic properties provide relief from discomfort and pain.

Upstream product

• 14173-39-8 p-chlorophenylalanine 

Downstream Products

• 882155-64-8 (S)-3-(4-chlorophenyl)-1-p-toluenesulfonyl-2-propanol 
• 565176-98-9 (R)-1-(4′-chlorophenyl)-2-propanol 
• 882151-98-6 (S)-3-(4-chlorophenyl)-1,2-propanediol 

Relevant academic research and scientific papers

Highly enantioselective stereo-inverting sec-alkylsulfatase activity of hyperthermophilic Archaea

rac-sec-Alkyl sulfate esters 1a-8a were resolved in low to excellent enantioselectivities with E-values up to > 200 using whole cells of aerobically-grown hyperthermophilic sulfur-metabolizers, such as Sulfolobus solfataricus DSM 1617, Sulfolobus shibatae DSM 5389 and, most notably, Sulfolobus acidocaldarius DSM 639. Significantly enhanced selectivities were obtained using cells grown on sucrose-enriched Brock-medium. The stereochemical course of this biohydrolysis was shown to proceed with strict inversion of configuration, thus the preferred (R)-enantiomers were converted into the corresponding (S)-sec-alcohols to furnish a homochiral product mixture. The Royal Society of Chemistry 2005.

Biocatalytic racemization of aliphatic, arylaliphatic, and aromatic α-hydroxycarboxylic acids

Biocatalytic racemization of a range of aliphatic, (aryl)aliphatic, and aromatic α-hydroxycarboxylic acids was accomplished by using whole resting cells of a range of Lactobacillus spp. The mild (physiological) reaction conditions ensured an essentially "clean" isomerization in the absence of side reactions, such as elimination or decomposition. Whereas straight-chain aliphatic 2-hydroxy-carboxylic acids were racemized with excellent rates (up to 85% relative to lactate), steric hindrance was observed for branched-chain analogues. Good rates were observed for aryl-alkyl derivatives, such as 3-phenyllactic acid (up to 59%) and 4-phenyl-2-hydroxybutanoic acid (up to 47%). In addition, also mandelate and its o-chloro analogue were accepted at a fair rate (45%). This biocatalytic racemization represents an important tool for the deracemization of a number of pharmaceutically important building blocks.