494798-48-0

Upstream product

• 494798-47-9 5′-C(S)-tosyloxyethyl-3′-O-(tert-butyldiphenylsilyl)thymidine 
• 98-59-9 p-toluenesulfonyl chloride 
• 494798-45-7 3'-O-tert-butyldiphenylsilyl-5'-C(S)-methyl ethanoate-thymidine 
• 494798-46-8 3'-O-tert-butyldiphenylsilyl-5'-C(S)-2-hydroxyethyl-thymidine 
• 146604-43-5 1-(2-deoxy-3-O-tert-butyldiphenylsilyl-β-D-erythro-pentadialdo-1,4-furanosyl)-5-methyluracil 

Relevant academic research and scientific papers

Diastereoselective synthesis of a conformationally restricted dinucleotide with predefined alpha and beta torsional angles for the construction of alpha,beta-constrained nucleic acids (alpha,beta-CNA).

[reaction: see text] The synthesis of a diastereopure 1,3,2-dioxaphosphorinane linkage in which two, alpha and beta, out of six torsion angles of the natural phosphodiester backbone are constrained with predefined values of ca. +60 degrees (g(+)) and 180