494802-93-6

Downstream Products

• 334824-70-3 [(S)-2-(4-Chloro-phenyl)-pent-4-enyl]-methyl-amine 
• 334824-61-2 (S)-2-(4-Chloro-phenyl)-pent-4-enoic acid methylamide 
• 334824-87-2 N-[2-(4-chloro-phenyl)-4-oxo-butyl]-N-methyl-benzenesulfonamide 
• 334824-78-1 N-[2-(4-chloro-phenyl)-pent-4-enyl]-N-methyl-benzenesulfonamide 
• 959354-10-0 C₂₉H₃₃ClN₂O₂S₂ 
• 1208553-13-2 C₁₄H₁₃ClN₂OS 

Relevant academic research and scientific papers

The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators

Free fatty acid receptor 2 (FFA2) is a G-protein coupled receptor for which only short-chain fatty acids (SCFAs) have been reported as endogenous ligands. We describe the discovery and optimization of phenylacetamides as allosteric agonists of FFA2. These novel ligands can suppress adipocyte lipolysis in vitro and reduce plasma FFA levels in vivo, suggesting that these allosteric modulators can serve as pharmacological tools for exploring the potential function of FFA2 in various disease conditions.

Synthesis of enantiomerically enriched (S)-(+)-2-aryl-4-pentenoic acids and (R)-(-)-2-aryl-4-pentenamides via microbial hydrolysis of nitriles, a chemoenzymatic approach to stereoisomers of α,γ-disubstituted γ-butyrolactones

In the presence of the nitrile hydratase/amidase-containing Rhodococcus sp. AJ270 whole cell catalyst, 2-aryl-4-pentenenitriles 1 underwent enantioselective hydrolysis under mild conditions to afford (R)-(-)-2-aryl-4-pentenoic acid amides 2 and (S)-(+)-2-

Highly enantioselective biotransformations of 2-aryl-4-pentenenitriles, a novel chemoenzymatic approach to (R)-(-)-baclofen

Catalyzed by Rhodococcus sp. AJ270 microbial cells under mild conditions, a range of racemic 2-aryl-4-pentenenitriles 1 underwent effective hydrolysis to afford excellent yields of enantiomerically pure (R)-(-)-2-aryl-4-pentenamides 2 and (S)-(+)-2-aryl-4-pentenoic acids 3 in most cases. The application of this biotransformation has been shown by a two-step synthesis of (R)-(-)-baclofen.