494803-12-2

Upstream product

• 132836-66-9 (S)-3-acetyl-4-benzyloxazolidin-2-one 
• 555-16-8 4-nitrobenzaldehdye 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 494803-05-3 (3'S,4S)-4-benzyl-3-[3'-hydroxy-3'-(4-nitrophenyl)propionyl]oxazolidin-2-one 

Downstream Products

• 494803-19-9 (4S)-4-(tert-butyldimethylsilanyloxy)-4-(4-nitrophenyl)butan-2-one 
• 494803-24-6 (4S)-4-(tert-butyldimethylsilanyloxy)-1-methoxy-4-(4-nitrophenyl)butan-2-one 
• 494803-22-4 (4S)-4-(tert-butyldimethylsilanyloxy)-1-methylsulfanyl-4-(4-nitrophenyl)butan-2-one 
• 494803-20-2 (4S)-4-(tert-butyldimethylsilanyloxy)-1-chloro-4-(4-nitrophenyl)butan-2-one 
• 494803-23-5 (4S)-4-(tert-butyldimethylsilanyloxy)-1-hydroxy-4-(4-nitrophenyl)butan-2-one 
• 494803-16-6 (1S)-1-(tert-butyldimethylsilanyloxy)-1-(4-nitrophenyl)heptan-3-one 
• 494803-14-4 (3S)-3-(tert-butyldimethylsilanyloxy)-3-(4-nitrophenyl)propionic acid 

Relevant academic research and scientific papers

Asymmetric synthesis of aldol products derived from unsymmetrical ketones: Assignment of the absolute configuration of antibody aldol products

Compounds 1-7 are the products formed by aldol condensation of p-nitrobenzaldehyde with a series of unsymmetrical ketones, the reaction occurring at the less substituted carbon. The asymmetric synthesis of 1-7 using the Evans's asymmetric aldol methodology is described in detail. These syntheses were completed to allow us to assign the absolute configuration of products 1-3, obtained in a single step in the presence of the aldolase I antibody 84G3.