494844-16-5Relevant academic research and scientific papers
Design, synthesis and biological activity of rigid cannabinoid CB1 receptor antagonists.
Stoit, Axel Reinhard,Lange, Jos Hubertus Maria,Hartog, Arnold Peter den,Ronken, Eric,Tipker, Koos,Stuivenberg, Herman Heinrich van,Dijksman, Jessica Adriana Rigtje,Wals, Henri Cornelis,Kruse, Chris Gerrit
, p. 1109 - 1113 (2007/10/03)
The design, synthesis and biological activities of potent pyrazole-based tricyclic CB1 receptor antagonists (2) are described. The key synthetic step involves the ring closure of the lithiated alpha, gamma-keto ester adduct (4). The optimal nitroderivativ
