494863-58-0Relevant academic research and scientific papers
Synthesis and evaluation as NOP ligands of some spiro[piperidine-4, 2′(1′H)-quinazolin]-4′(3′H)-ones and spiro[piperidine-4,5′(6′H)-[1,2,4]triazolo[1,5-c]quinazolines]
Mustazza, Carlo,Borioni, Anna,Sestili, Isabella,Sbraccia, Maria,Rodomonte, Andrea,Ferretti, Rosella,Del Giudice, Maria Rosaria
, p. 611 - 622 (2007/10/03)
Some spiro[piperidine-4,2′(1′H)-quinazolin]-4′(3′H) -ones 3 and spiro[piperidine-4,5′(6′H)-[1,2,4]triazolo-1,5-c] quinazolines] 4 were synthesized and evaluated as ligands of the nociceptin receptor. The examined compounds showed partial agonistic activity, except compounds 3, 4n that proved to be pure antagonists.
Novel hexahydrospiro[piperidine-4,1′-pyrrolo[3,4-c]pyrroles: Highly selective small-molecule nociceptin/orphanin FQ receptor agonists
Kolczewski, Sabine,Adam, Geo,Cesura, Andrea M.,Jenck, Fran?ois,Hennig, Michael,Oberhauser, Thomas,Poli, Sonia M.,R?ssler, Felix,R?ver, Stephan,Wichmann, Jürgen,Dautzenberg, Frank M.
, p. 255 - 264 (2007/10/03)
Novel hexahydrospiro[piperidine-4,1′-pyrrolo[3,4-c]pyrroles that act as potent and selective orphanin FQ/nociceptin (N/OFQ) receptor (NOP) agonists were identified. The best compound, (+)-5a, potently inhibited 3H-N/OFQ binding to the NOP recep
