495381-15-2

Upstream product

• 142363-27-7 (S)-6-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-5-methyl-3-phenyl-6H-[1,2]oxazine 
• 142363-23-3 (5R,6R)-6-[(3aS,5S,6R,6aS)-5-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-5-methyl-3-phenyl-5,6-dihydro-4H-[1,2]oxazine 
• 21572-32-7 2-chloro-1-phenyl-ethanone oxime 
• 142363-26-6 (S)-6-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-5-methylene-3-phenyl-5,6-dihydro-4H-[1,2]oxazine 
• 1349191-65-6 (S)-N-benzyl-2-methyl-4-phenyl-but-3-yn-1-amine 

Relevant academic research and scientific papers

Reactivity of cyclic sulfamidates towards lithium acetylides: Synthesis of alkynylated amines

A synthetically useful level of reactivity of cyclic sulfamidates toward acetylides is described. Ring-opening reactions of a structurally diverse set of 1,2-and 1,3-cyclic sulfamidates with a range of lithium acetylides from aliphatic, cyclic, aromatic, heteroaromatic, and functionalized alkynes proceed smoothly in a regioselective manner to give the corresponding N-sulfate intermediates. Hydrolysis of these intermediates under acidic conditions furnishes the alkynylated amines in yields ranging from 29% to 98%. The scope of the acetylenic substitution reaction with the structural variations in both the cyclic sulfamidates and alkynes is briefly examined.

Hetero Diels-Alder reactions of nitroso alkenes with alkoxyallene derivatives bearing carbohydrate auxiliaries: Asymmetric synthesis of 6H-1,2-oxazines and subsequent reductive transformations

Alkoxyallene derivatives 1a-f bearing carbohydrate auxiliaries at the oxygen were examined in asymmetric hetero Diels-Alder reactions with nitroso alkenes. Diacetoneglucose derived compound aa turned out to be the best precursor furnishing the primary cyc