495405-49-7

Upstream product

• 144285-08-5 2-{[(E)-(S)-1-Hydroxymethyl-3-methyl-butylimino]-methyl}-phenol 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 89-95-2 2-methyl-benzyl alcohol 
• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 495405-46-4 (S)-2-{[1-(2-Hydroxy-phenyl)-meth-(E)-ylidene]-amino}-4-methyl-pentanoic acid methyl ester 

Relevant academic research and scientific papers

Highly enantioselective titanium-catalyzed cyanation of imines at room temperature

(Figure presented) A highly active and enantioselective titanium-catalyzed cyanatlon of imines at room temperature Is described. The catalyst used Is a partially hydrolyzed titanium alkoxide (PHTA) precatalyst together with a readily available N-salicyl-β-aminoalcohol ligand. Up to 98% ee was obtained with quantitative yields In 15 min of reaction time using 5 mol % of the catalyst. Various N-protecting groups such as benzyl, benzhydryl, Boc, and PMP are tolerated.

Synthesis of new tridentate chiral aminoalcohols by a multicomponent reaction and their evaluation as ligands for catalytic asymmetric Strecker reaction

A one-step, multicomponent Mannich-type reaction between phenols, paraformaldehyde, and β-aminoalcohols in the presence of LiCl afforded N-2-hydroxybenzyloxazolidines with high ortho-selectivity. Hydrolytic or reductive ring opening of the oxazolidines pr

A highly enantioselective Strecker reaction catalyzed by titanium-N-salicyl-β-aminoalcohol complexes

N-salicyl-β-amino alcohols 1 were synthesized and evaluated as ligands for catalytic asymmetric Strecker reactions. N-Benzhydrylaldimines derived from aromatic and aliphatic aldehydes reacted with TMSCN in the presence of 10 mol% of Ti-1 complex to give t

Synthesis of novel chiral auxiliaries

A simple and easy route for the preparation of the higher homologue of oxazaborolidine namely dihydrooxazaborin has been reported. Also, the preparations of new bicyclic oxazaborolidines are reported.