495406-75-2

Upstream product

• 930-30-3 cyclopent-2-enone 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 1156004-24-8 2-[(phenylamino)(4-chlorophenyl)methyl]cyclopent-2-enone 
• 1156004-29-3 2-[(4-fluorophenylamino)(4-chlorophenyl)methyl]cyclopent-2-enone 
• 1173285-01-2 C₂₀H₁₇ClO₂ 
• 1207189-25-0 C₂₁H₁₈ClNO 
• 1198078-51-1 2-((4-chlorophenyl)(5-oxocyclopent-1-enyl)methyl)-1,3-diphenylpropane-1,3-dione 
• 1258065-65-4 (E)-2-(4-chlorobenzylidene)-4-(1H-indol-3-yl)cyclopentanone 
• 1328916-05-7 C₁₂H₁₁ClO₂ 
• 1357349-12-2 C₁₂H₁₁ClO₂ 
• 1304666-12-3 C₂₁H₂₁ClO₄ 

Relevant academic research and scientific papers

Endohedral Functionalized Cage as a Tool to Create Frustrated Lewis Pairs

A frustrated Lewis pair (FLP) system was obtained by confinement of the Lewis base partner, a Verkade's superbase, in a molecular cavity. Whereas the model superbase lacking cavity displayed no catalytic activity in Morita–Baylis–Hillman (MBH) reactions,

Baylis-Hillman reaction of cyclic enones with arenecarbaldehydes and N-arylidene-4-methylbenzenesulfonamides by using NAP-MgO

Baylis-Hillman reaction of cyclic enones with arenecarbaldehydes and N-arylidene-4-methylbenzenesulfonamides under mild conditions by using nanocrystalline MgO (NAP-MgO) afforded the Baylis-Hillman adducts in moderate to good yields with higher selectivit

Remarkable Rate Acceleration of Imidazole-Promoted Baylis-Hillman Reaction Involving Cyclic Enones in Basic Water Solution

The Baylis-Hillman reaction of cyclic enones was greatly accelerated in basic water solution with imidazoles as catalysts, which resulted in short reaction time, high yields, and expanding substrate scopes. Bicarbonate solution was shown to be the optimal

The azoles: Effective catalysts for Baylis-Hillman reaction in basic water solution

The azoles, which were inactive in neutral aqueous media, could be activated in alkaline solution and effectively catalyze the Baylis-Hillman reaction involving cyclic enones.

Efficient Baylis-Hillman reactions of cyclic enones in methanol as catalyzed by methoxide anion

The Baylis-Hillman reactions of cyclic enones with a variety of aldehydes were investigated. 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) was found to be a viable catalyst in promoting the reactions of sterically retarded substrates in methanol. The reactions showed clear solvent dependence and only occurred in hydroxylic solvents, especially in methanol. Further consideration on the steric character of DBU and its high basicity jointly with other experimental observations suggests that the methoxide anion should be the "true" Baylis-Hillman catalyst. This has been confirmed by the effectiveness of similar reactions directly employing methoxide as the catalyst. The reaction pathways of this type of catalysis are proposed to depend on the choice of substrates. Supporting experimental observations were demonstrated and discussed in relation to mechanistic considerations. This study also reveals that both DBU and sodium methoxide can be successfully applied as effective catalysts in methanol to promote the Baylis-Hillman reactions for a range of cyclic enones including cyclopent-2-enones, cyclohex-2-enones, γ-pyrone, and 1-benzopyran-4(4H)- ones.

Lewis base effects in the Baylis-Hillman reaction of arenecarbaldehydes and N-arylidene-4-methylbenzenesulfonamides with α,β-unsaturated cyclic ketones

In investigations into the Baylis-Hillman reaction between arenecarbaldehydes and 2-cyclohexen-1-one or 2-cyclopenten-1-one, we found that the reaction is very complicated, because the Lewis bases, solvents, the substrates, and the ring-size of the α,β-un

Aqueous Baylis-Hillman reactions of cyclopent-2-enone using imidazole as catalyst

In aqueous media, imidazole was found to catalyse Baylis-Hillman reactions of cyclopent-2-enone with various aldehydes to afford the desired adducts with high yields.