495419-56-2

Usage

Derivative of

1,8-Naphthyridine

Heterocyclic compound

Fused pyridine and dihydropyridine ring

Common use

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Utilization

Production of various chemical products

Physical state

Colorless to pale yellow liquid

Odor

Characteristic

Solubility

Soluble in organic solvents such as ethanol and ether

Safety precautions

Can be harmful if inhaled, ingested, or in contact with the skin

Upstream product

• 7521-41-7 2-Aminonicotinaldehyde 
• 539-88-8 4-oxopentanoic acid ethyl ester 

Relevant academic research and scientific papers

Highly regioselective friedlaender reaction

Matrix presented A highly regioselective Friedlaender reaction is described. By introduction of a phosphonate group at one of the α-carbons of a ketone, regioselectivity can be perfectly controlled.

Highly regioselective Friedlaender annulations with unmodified ketones employing novel amine catalysts: Syntheses of 2-substituted quinolines, 1,8-naphthyridines, and related heterocycles

Catalysts were evaluated on the preparation of 2-substituted quinolines, 1,8-naphthyridines, and chromone derivatives from unmodified methyl ketones and o-aminoaromatic aldehydes. While oxide catalysts yielded the 2,3-dialkyl substituted products, cyclic

AMINO ACID COMPOUNDS AND METHODS OF USE

The invention relates to compounds of formula (I): or a salt thereof, wherein R1, G, L1, L2, L3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, αvβ1 integrin and αvβ6 integrin that are useful for treating fibrosis such as in nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

N-ACYL AMINO ACID COMPOUNDS AND METHODS OF USE

The invention relates to compounds of formula (I), or a salt thereof wherein R1, A, L, and R2 and n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ανβ1 integrin inhibitors that are useful for treating tissue specific fibrosis.

CYCLOBUTANE- AND AZETIDINE-CONTAINING MONO AND SPIROCYCLIC COMPOUNDS AS ALPHA V INTEGRIN INHIBITORS

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to αv- containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of av-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.