4957-19-1

Upstream product

• 119925-07-4 (E)-1-methoxy-2-(3-methylbut-1-en-1-yl)benzene 
• 135-02-4 ortho-anisaldehyde 
• 854179-04-7 1-(2-methoxy-phenyl)-3-methyl-butan-1-ol 

Downstream Products

• 5032-03-1 (3-methyl-butyl)-phenol 
• 1265882-35-6 4-cyclohexyl-2-methoxy-1-(3-methylbutyl)benzene 
• 1265882-33-4 6-cyclohexyl-4-methoxy-1,1-dimethylindane 
• 79699-55-1 1,1-dimethyl-4-methoxyindan 
• 1265882-40-3 4-(2-hexyl)-1-(3-methylbutyl)-2-methoxybenzene 
• 1265882-39-0 1-(3-methylbutyl)-2-methoxy-4-(1-phenylethyl)benzene 
• 143999-39-7 3.5-dinitro-2-hydroxy-1-isopentyl-benzene 

Relevant academic research and scientific papers

Catalytic Intermolecular C(sp3)-H Amination: Selective Functionalization of Tertiary C-H Bonds vs Activated Benzylic C-H Bonds

A catalytic intermolecular amination of nonactivated tertiary C(sp3)-H bonds (BDE of 96 kcal·mol-1) is reported for substrates displaying an activated benzylic site (BDE of 85 kcal·mol-1). The tertiary C(sp3)-H bond is selectively functionalized to afford α,α,α-Trisubstituted amides in high yields. This unusual site-selectivity results from the synergistic combination of Rh2(S-Tfpttl)4, a rhodium(II) complex with a well-defined catalytic pocket, with tert-butylphenol sulfamate (TBPhsNH2), which leads to a discriminating rhodium-bound nitrene species under mild oxidative conditions. This catalytic system is very robust, and the reaction was performed on a 50 mmol scale with only 0.01 mol % of catalyst. The TBPhs group can be removed under mild conditions to afford the corresponding NH-free amines.