49570-33-4Relevant academic research and scientific papers
ISOTHIAZOLE-PYRIDINE DERIVATIVES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY
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Page/Page column 66, (2009/09/04)
The present invention relates to novel compounds according to Formula I or II, methods, and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF). Formula (I) or (II).
Nitrile Sulphides. Part 3. Thermal Fragmentation of 1,3,4-Oxathiazoles: Formation of Nitrile Sulphides in a Retro-1,3-dipolar Cycloaddition Reaction
Paton, R. Michael,Robertson, Fiona M.,Ross, John F.,Crosby, John
, p. 1517 - 1522 (2007/10/02)
On thermolysis at ca. 160 gradC 1,3,4-oxathiazoles undergo retro-1,3-dipolar cycloaddition forming nitrile sulphides and carbonyl-containing fragments.The nitrile sulphides either decompose to sulphur and nitriles or are trapped as their 1,3-dipolar cycloadducts in the presence of dipolarophiles (dimethyl acetylenedicarboxylate, ethyl cyanoformate, benzonitrile, ethyl propiolate).Similar ratios (1.32, l.34, 1.33, 1.31) of 4- and 5-ethoxycarbonyl-3-(p-methoxyphenyl)isothiazole obtained from four sources of p-methoxybenzonitrile sulphide with ethyl propriolate provide strong evidence for product formation from a discrete intermediate nitrile sulphide rather than via direct interaction of precursor with dipolarophile. 2-Dichloromethylene-1,3,4-oxathiazoles, prepared by dehydrochlorination of 2-trichloromethyloxathiazoles, prepared by dehydrochlorination of 2-trichlorometyloxathiazoles, likewise fragment to nitrile sulphides, but attempts to trap dichloroketene were unsuccessful.
THE THERMAL FRAGMENTATION OF 1,3,4-DITHIAZOL-2-ONES
Greig, Derek J.,Paton, R. Michael,Rankin, John G.,Ross, John F.,Crosby, John
, p. 5453 - 5454 (2007/10/02)
Thermal expulsion of carbon oxysulphide from 1,3,4-dithiazol-2-ones in the presence of DMAD affords nitrile sulphide-derived dimethyl isothiazole-4,5-dicarboxylates.
Nitrile Sulphide Formation from the Thermal Fragmentation of 1,3,4-Oxathiazoles: a Retro-1,3-dipolar Cycloaddition
Paton, R. Michael,Robertson, Fiona M.,Ross, John F.,Crosby, John
, p. 714 - 715 (2007/10/02)
1,3,4-Oxathiazoles, on thermolysis, undergo retro-1,3-dipolar cycloaddition to afford carbonyl compounds and nitrile sulphides, which may be trapped by cycloaddition with alkynes and nitriles.
Some 1,3-Dipolar Cycloaddition Reactions of Nitrile N-Sulfides with Acetylenes and Olefins
Sanders, Michael J.,Grunwell, John R.
, p. 3753 - 3756 (2007/10/02)
The generation of nitrile N-sulfides from iminosulfur difluorides is general.Trifluoroacetonitrile N-sulfide was allowed to react with some acetylenes and olefins.For example, N-phenylmaleimide gave N-phenyl-3-trifluoromethyl-1,2-thiazoline-4,5-carboximid
