49571-72-4Relevant academic research and scientific papers
Rapid One-pot Solid-phase Synthesis of 1,2,4-Oxadiazolines
Lin, Xu-Feng,Cui, Sun-Liang,Wang, Yan-Guang
, p. 842 - 843 (2003)
The first solid phase synthesis of 1,2,4-oxadiazolines via 1,3-dipolar cycloaddition of nitrile oxide generated in situ on solid support with a variety of imines is described. The synthetic sequences were performed in parallel one-pot fashion. Cleavage from the support under two different mild conditions afforded a library of 1,2,4-oxadiazolines in good yields and purity.
