49572-80-7Relevant academic research and scientific papers
Khellinone Derivatives as Blockers of the Voltage-Gated Potassium Channel Kv1.3: Synthesis and Immunosuppressive Activity
Baell, Jonathan B.,Gable, Robert W.,Harvey, Andrew J.,Toovey, Nathan,Herzog, Tanja,H?nsel, Wolfram,Wulff, Heike
, p. 2326 - 2336 (2004)
The voltage-gated potassium channel Kv1.3 constitutes a promising new target for the treatment of T-cell-mediated autoimmune diseases such as multiple sclerosis. In this study, we report the discovery of two new classes of Kv1.3 blockers based on the natu
NOVEL CHALCONE DERIVATIVES AND USES THEREOF
-
Page/Page column 39; 44, (2008/06/13)
Various chalcone derivatives of the general formula (I) are described and the variables, A, B, m and R1 to R10 are as defined in the specification. These derivatives can be useful in the modulation of potassium channel activity in ce
MICROBIAL OXIDATION OF DIHYDROXYCHALCONE AND THE FORMATION OF A NOVEL FLAVANOID QUINOL ETHER
El-Diwani, H. I.,El-Menofi, H. A.
, p. 365 - 367 (2007/10/02)
A number of organisms were tested for the biological oxidation of the dihydroxy chalcone (1).Only Trichoderma aureoviride gave good results.A new flavanoid quinol ether compound (3) was obtained different from the aurone obtained from chemical oxidation of the chalcone using sodium hydroxide and hydrogen peroxide.Key words: Dihydroxy chalcone, Biological oxidation, Trichoderma aureoviride.
