49572-99-8

Usage

Uses

Used in Pharmaceutical Industry:
1(2H)-Phthalazinone, 2-methyl-4-phenylis used as a building block for the synthesis of various drugs and pharmaceuticals. Its unique chemical structure allows for the creation of a wide range of therapeutic agents, making it a valuable asset in the development of new medications.
Used in Research and Development:
In the field of research and development, 1(2H)-Phthalazinone, 2-methyl-4-phenylis employed for its potential therapeutic applications. Its biological activities are being studied to explore its use in the treatment of various medical conditions, contributing to the advancement of medical science and the development of novel treatment options.
Used in Treatment of Medical Conditions:
1(2H)-Phthalazinone, 2-methyl-4-phenylhas been studied for its potential use in the treatment of various medical conditions. Its biological activities and unique chemical structure make it a promising candidate for further research and development, with the aim of discovering new therapeutic agents to address a range of health issues.

Upstream product

• 622-36-6 1-methyl-2-phenylhydrazine 
• 119-67-5 o-carboxybenzaldehyde 
• 85-52-9 2-Benzoylbenzoic acid 
• 60-34-4 methylhydrazine 
• 5004-45-5 4-phenyl-2H-phthalazin-1-one 
• 74-88-4 methyl iodide 
• 59142-47-1 (2-bromophenyl)phenylmethanol 
• 6630-33-7 ortho-bromobenzaldehyde 
• 15226-74-1 dicobalt octacarbonyl 
• 13047-06-8 o-bromobenzophenone 
• 7339-53-9 methyl hydrazine hydrochloride 
• 1427283-37-1 N′-benzylidene-2-iodo-N-methylbenzohydrazide 

Downstream Products

• 142152-90-7 N-methyl-α'-phenyl-1,2-phenylenedimethanamine 
• 134390-04-8 α,α'-diphenyl-N-methylbenzenedimethanamine dihydrochloride 

Relevant academic research and scientific papers

TOLL-LIKE RECEPTOR 8 (TLR8)-SPECIFIC ANTAGONISTS AND METHODS OF MAKING AND USES THEREOF

Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder.

Convenient method for the synthesis of phthalazinones via carbonylation of 2-bromobenzaldehyde using Co2(CO)8 as a CO source

A simple one-pot synthesis of phthalazinones by the condensation and intra-molecular carbonylative cyclization of 2-bromobenzaldehydes with hydrazines is reported. This method utilizes solid Co2(CO) 8 as carbonyl source making it rea

Synthesis of phthalazinones via palladium(ii)-catalysed intramolecular oxidative C-H/C-H cross-coupling of N′-methylenebenzohydrazides

A palladium(ii)-catalysed intramolecular oxidative C-H/C-H cross-coupling of N′-methylenebenzohydrazides to phthalazin-1(2H)-ones has been developed. This cyclization is believed to mechanistically proceed via electrophilic ortho-palladation and subsequen

Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents

Aryl-fused- and hetaryl-fused-2,4-diazepines of formula XXXVI, benzodiazocines of formula XXX, benzodiazepines of formula II STR1 δ-aminoamides of formula III and aryldimethanamines of formula XXXVII STR2 wherein A is an aryl or hetaryl ring; R1 is hydrogen, alkyl, aryl or hetaryl; R2 is hydrogen, alkyl, substituted alkyl, or aryl; R3 is alkyl, aryl, aralkyl or heteroatom substituted alkyl or aralkyl; R4 is hydrogen or alkyl; R5 is hydrogen, alkyl, aryl or hetaryl; R6 is hydrogen, alkyl, alkoxy, halogen or a fused benzene ring; R9 is hydrogen, alkyl, or substituted alkyl; and R10 is hydrogen, alkyl, or substituted alkyl. The invention further relates to processes for the preparation of, pharmaceutical compositions containing, and methods of treating cardiac arrhythmia with the compounds of formulas XXXVI, XXX, II, III, and XXXVII.

ALKYLATION OF 1-0X0-2-PHENYL(METHYL)-4-ARYL(METHYL)-1,2-DIHYDROPHTHALAZINES WITH TRIETHYLOXONIUM FLUOROBORATE

1-Oxo-2-phenyl-4-aryl-1,2-dihydrophthalazines are alkylated by triethyloxonium fluoroborate at the N3 nitrogen atom, forming corresponding 1-oxo-1,2-dihydrophthalazinium tetrafluoroborates.Under the same conditions 1-oxo-2-methyl-4-phenyl(methy