49579-40-0Relevant academic research and scientific papers
Preparation method of 2 -trifluoromethyl-substituted quinazolinone derivative (by machine translation)
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Paragraph 0033-0039; 0042-0048, (2021/01/04)
The invention discloses a preparation method of 2 -trifluoromethyl-substituted quinazolinone derivatives, which comprises the following steps: a palladium catalyst is prepared. Ligands, carbon monoxide alternatives, additives, trifluoroethylimino chloride and o-iodoanilines are added to the organic solvent. Reaction 90 °C was carried out 16 - 30 hours, and after completion of the reaction, the resulting 2 -trifluoromethyl-substituted quinazolinone derivative was obtained. The preparation method is simple and convenient to operate, the reaction starting materials are cheap and easily available, various substituent groups can be compatible, the substrate applicability is good, the substituted trifluoromethyl quinazolinone derivatives with different groups can be synthesized through substrate design, operation is facilitated, and the practicability of the method is widened. To the method, 1,tricarboxylic acid phenol ester is the solid carbon monoxide substitute, has avoided poisonous and colorless gaseous carbon monoxide's use . (by machine translation)
FeCl3-Mediated Synthesis of 2-(Trifluoromethyl)quinazolin-4(3 H)-ones from Isatins and Trifluoroacetimidoyl Chlorides
Wang, Le-Cheng,Du, Shiying,Chen, Zhengkai,Wu, Xiao-Feng
, p. 5567 - 5571 (2020/07/14)
An FeCl3-mediated cascade coupling/decarbonylative annulation reaction for the efficient construction of 2-(trifluoromethyl)quinazolin-4(3H)-ones has been developed. This transformation employs readily available isatins and trifluoroacetimidoyl chlorides as the starting materials, providing a facile and practical route to diverse biologically relevant quinazolin-4(3H)-one derivatives. A plausible reaction pathway has been proposed based on the mechanistic observations.
Preparation method of 2 - trifluoromethyl substituted quinazoline ketone compound (by machine translation)
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Paragraph 0034-0041; 0049-0055, (2020/09/30)
The invention discloses a preparation method of 2 -trifluoromethyl-substituted quinazolone compounds, which comprises the following steps: ferric trichloride and sodium hydrogen. The molecular sieve, trifluoroethyl imine acyl chloride and indirubin were a
