4959-16-4

Usage

Uses

Used in Forensic Applications:
7-Aminonimetazepam is used as a forensic tool for detecting the presence of nimetazepam in urine specimens, which can be crucial in cases involving drug abuse or intoxication.
Used in Research Applications:
7-Aminonimetazepam serves as a research compound for studying the metabolism and pharmacokinetics of nimetazepam, as well as its potential physiological and toxicological effects. This can contribute to a better understanding of benzodiazepine compounds and their impact on the human body.

Upstream product

• 2011-67-8 nimetazepam 

Downstream Products

• 1082051-80-6 ethyl 8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-7-ylamino)-8-oxooctanoate 
• 1082051-77-1 7-iodo-1-methyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one 

Relevant academic research and scientific papers

Substrate selectivity of human aldehyde oxidase 1 in reduction of nitroaromatic drugs

Human aldehyde oxidase 1 (AOX1) catalyzes the oxidation of various drugs and endogenous compounds. Recently, we found that AOX1 catalyzed the reduction of drugs such as nitrazepam and dantrolene. In this study, we aimed to clarify the substrate selectivit

5-PHENYL-LH-BENZ0 [E] [1, 4] DIAZEPINE COMPOUNDS SUBSTITUTED WITH AN HYDROXAMIC ACID GROUP AS HISTONE DEACETYLASE INHIBITORS

Novel hydroxamate histone deacetylase inhibitors of formula (I) wherein X is C=O or CH2 used as antineoplastic agent.

Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents

This study concerns the synthesis of new histone deacetylase inhibitors (HDACi) characterized by a 1,4-benzodiazepine ring used as the cap, joined through an amide function or a triple bond as connection units, to a linear alkyl chain bearing the hydroxamate function as Zn2+-chelating group. Biological tests performed in human acute promyelocytic leukemia NB4 cells showed that new hybrids can induce histone H3/H4 acetylation, growth arrest, and also apoptosis. Notably, chiral compounds exhibit stereoselective activity.

Coulometric determination of several water-insoluble aromatic nitro compounds with electrogenerated chromium(II)

The electrochemical reduction of a series of water-insoluble aromatic nitro compounds with coulometrically generated chromium(II) has been investigated.Samples ranging from 0.2 to 0.5 μmol could be determined for several substances with a precision and accuracy of about 1percent.The number of electrons involved in the reductions corresponded in most cases to the formation of hydroxylamines or amines, but in some instances to dihydrazo products.