49599-17-9

Usage

Chemical Class

Isoindolinone derivatives

Physical Appearance

White to off-white solid

Potential Applications

Pharmaceuticals and organic synthesis

Bromine Content

Contains a bromine atom attached to the acetyl group

Reactivity

Exhibits reactivity as an acylating agent in various chemical reactions

Synthesis Utility

Can serve as a starting material for the synthesis of complex organic molecules

Core Structure

Isoindoline-1,3-dione core structure gives it potential as a versatile building block for the development of novel pharmaceutical compounds and materials.

Upstream product

• 1971-49-9 N-acetylphthalimide 

Relevant academic research and scientific papers

Simple method for synthesis of isolated heterocyclic compounds incorporating 2-(2-bromoacetyl)isoindoline-1,3-dione and 2-(2-cyanoacetyl)isoindoline-1,3-dione

2-(2-Bromoacetyl)isoindoline-1,3-dione 2 and 2-(2-cyanoacetyl)isoindoline-1,3-dione 3 have been used as starting intermediates for synthesis of functionalized heterocyclic derivatives such as, 2-(2-aminothiazol-5-yl)isoindoline-1,3-dione 4, 2-(2-(benzylideneamino)thiazol-5-yl)isoindoline-1,3-dione 5, 2-(2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)thiazol-5- yl)isoindoline-1,3-dione 6, 2-(2-(4-oxo-2-phenylthiazolidin-3-yl)thiazol-5-yl)isoindoline-1,3-dione 7, 2-(2-arylhydrazono)- 2-bromo(cyano)acetyl)-isoindoline-1,3-dione 8, 6-bromo-5-(1,3-dioxoisoindolin-2-yl)-3-oxo-2-phenyl-2,3-dihydropyridazine- 4-carbonitrile 10a, 4-(1,3-dioxoisoindolin-2-yl)-6-oxo-1-phenyl-1,6-dihydropyridazine-3,5-dicarbonitrile 10b, 1-acetyl-3- (1,3-dioxoisoindolin-2-yl)-5-aryl-4,5-dihydro-1H-pyrazole-4-carbonitrile 12, 4-cyano-3-(1,3-dioxoisoindolin-2-yl)-5-aryl- 4,5-dihydro-1H-pyrazole-1-carbothioamide 13, 3-(1,3-dioxoisoindolin-2-yl)-1-(4-oxo-4,5-dihydrothiazol-2-yl)-5-phenyl- 4,5-dihydro-1H-pyrazole-4-carbonitrile 14, 3-(1,3-dioxoisoindolin-2-yl)-1-(5-(1,3-dioxoisoindolin-2-yl)thiazol-2-yl)-5- phenyl-4,5-dihydro-1H-pyrazole-4-carbonitrile 15, 2-(3-amino-5-(phenylamino)-1H-pyrazole-4-carbonyl)isoindoline-1,3- dione 17, 2-(5,7-dimethyl-2-(phenyl-amino)pyrazolo[1,5-a]pyrimidine-3-carbonyl)isoindoline-1,3-dione 18 and 2-(7-phenyl-2- (phenyl-amino)pyrazolo[1,5-a]pyrimidine-3-carbonyl)isoindoline-1,3-dione 20. The synthesized compounds have been characterized by IR, MS, 1H NMR and 13C NMR spectral analysis.