49599-37-3

Upstream product

• 957-68-6 7-Aminocephalosporanic acid 
• 27267-35-2 7-formylamino-3-acetoxymethyl-3-cephem-4-carboxylic acid 
• 908093-98-1 diazodiphenylmethane 

Downstream Products

• 160785-87-5 benzhydryl 7-formamido-3-N-methylcarbamoyloxymethyl-2-cephem-4-carboxylate 
• 142966-87-8 (6R,7R)-3-(Azetidine-1-carbonyloxymethyl)-7-formylamino-5,8-dioxo-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 160785-80-8 (6R,7R)-7-Formylamino-5,8-dioxo-3-(pyrrolidine-1-carbonyloxymethyl)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 160785-86-4 benzhydryl 7-formamido-3-(1-piperidinyl)carbonyloxymethyl-2-cephem-4-carboxylate 
• 160785-79-5 (6R,7R)-7-Formylamino-3-{[(2-hydroxy-ethyl)-methyl-carbamoyloxy]-methyl}-5,8-dioxo-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 160785-77-3 (6R,7R)-3-(2-Fluoro-ethylcarbamoyloxymethyl)-7-formylamino-5,8-dioxo-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 160785-78-4 (6R,7R)-7-Formylamino-5,8-dioxo-3-(2,2,2-trifluoro-ethylcarbamoyloxymethyl)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 160785-89-7 (6R,7R)-3-Ethylcarbamoyloxymethyl-7-formylamino-5,8-dioxo-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 160785-90-0 (6R,7R)-7-Formylamino-3-isopropylcarbamoyloxymethyl-5,8-dioxo-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 142967-10-0 (6R,7R)-8-Oxo-3-(2,2,2-trifluoro-ethylcarbamoyloxymethyl)-7-{2-[2-(trityl-amino)-thiazol-4-yl]-2-[(Z)-trityloxyimino]-acetylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 142966-85-6 benzhydryl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido>-3-(1-piperidinyl)carbonyloxymethyl-3-cephem-4-carboxylate 
• 142966-92-5 (6R,7R)-3-{[(2-Hydroxy-ethyl)-methyl-carbamoyloxy]-methyl}-8-oxo-7-{2-[2-(trityl-amino)-thiazol-4-yl]-2-[(Z)-trityloxyimino]-acetylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 142967-09-7 (6R,7R)-3-(2-Fluoro-ethylcarbamoyloxymethyl)-8-oxo-7-{2-[2-(trityl-amino)-thiazol-4-yl]-2-[(Z)-trityloxyimino]-acetylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 143003-49-0 (6R,7R)-8-Oxo-3-(pyrrolidine-1-carbonyloxymethyl)-7-{2-[2-(trityl-amino)-thiazol-4-yl]-2-[(Z)-trityloxyimino]-acetylamino}-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

Studies on orally active cephalosporins. I. Synthesis and structure-activity relationships of new 3-substituted carbamoyloxymethyl cephalosporins

The synthesis and antibacterial activities of 7β-[2-(-aminothiazol-4-yl)-2-hydroxyiminoacetami-do]-3-N,N -dimethylcarbamoyloxymethyl-3-cephem-4-carboxylic acid (E1100) and its analogs are described, as well as oral absorbability and in vivo activities of

Process for the preparation of 3-hydroxymethyl cephalosporins

A process for the preparation of a 3-hydroxymethyl cephalosporin compound which comprises selectively hydrolyzing a 3-formyloxymethyl cephalosporin compound under acidic conditions in the presence of a protic solvent whereby a 3-hydroxymethyl cephalospori