496-82-2

Basic information

• Product Name: Cyclooctanone,2-hydroxy-
• CAS NO: 496-82-2
• Molecular Weight: 142.198
• Mol File: 496-82-2.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: Cyclooctanone,2-hydroxy- (CAS DataBase Reference)
• NIST Chemistry Reference: Cyclooctanone,2-hydroxy- (496-82-2)
• EPA Substance Registry System: Cyclooctanone,2-hydroxy- (496-82-2)

Safety Data

• Hazardous Substances Data: 496-82-2(Hazardous Substances Data)

Usage

General Description

2-Hydroxy-cyclooctanone is a chemical compound with the molecular formula C8H14O2. It is a cyclic ketone with a hydroxyl group attached to the second carbon atom in the cyclooctanone ring. Cyclooctanone,2-hydroxy- is often used as a building block in organic synthesis and is also employed as a starting material in the production of various pharmaceuticals, agrochemicals, and fragrances. It can undergo various chemical reactions such as oxidation, reduction, and substitution to yield a wide range of derivatives with different chemical and biological properties. Additionally, 2-hydroxy-cyclooctanone has potential applications in the field of polymer chemistry and materials science due to its unique structural and chemical characteristics.

Upstream product

• 931-88-4 1,2-cyclooctene 
• 931-88-4 cis-Cyclooctene 
• 39261-18-2 2-bromocyclooctan-1-one 
• 4277-32-1 1,2-cyclooctanediol 
• 50338-42-6 (E)-1-trimethylsilyloxy-1-cyclooctene 
• 27607-33-6 (1R,2S)-Cyclooctane-1,2-diol 
• 1612874-45-9 C₁₄H₁₉BO₂ 

Downstream Products

• 2050-23-9 diethyl suberate 
• 664987-43-3 cis-2,8-dihydroxy-1-methylenecyclooctane 
• 85866-03-1 (1S,2R)-Cyclooctane-1,2,3-triol 
• 664987-30-8 3-benzyloxy-1,2-cyclooctanedione 
• 85866-03-1 cyclooctane-1,2,3-triol 
• 664987-32-0 cis-2,3-dihydroxycyclooctanone 
• 85866-03-1 cyclooctane-1,2,3-triol 
• 664987-26-2 (2S,8R)-2,8-dihydroxycyclooctanone 
• 664987-26-2 trans-2,8-dihydroxycyclooctanone 
• 500573-04-6 2-benzyl-2-hydroxy-cyclooctanone 
• 163034-84-2 C₂₀H₂₀N₆O₄ 
• 906540-27-0 cyclooctane-1,2-dione 1,2-bis(p-nitrophenyl)hydrazone 
• 1732-09-8 dimethyl subarate 
• 634598-39-3 2-(benzyloxy)cyclooctanone 

Relevant articles and documents

g-C3N4/metal halide perovskite composites as photocatalysts for singlet oxygen generation processes for the preparation of various oxidized synthons

g-C3N4/metal halide perovskite composites were prepared and used for the first time as photocatalysts forin situ1O2generation to perform hetero Diels-Alder, ene and oxidation reactions with suitable dienes and alkenes. The standardized methodology was made applicable to a variety of olefinic substrates. The scope of the method is finely illustrated and the reactions afforded desymmetrized hydroxy-ketone derivatives, unsaturated ketones and epoxides. Some limitations were also observed, especially in the case of the alkene oxidations, and poor chemoselectivity was somewhere observed in this work which is the first application of MHP-based composites forin situ1O2generation. The experimental protocol can be used as a platform to further expand the knowledge and applicability of MHPs to organic reactions, since perovskites offer a rich variety of tuning strategies which may be explored to improve reaction yields and selectivities.

Polymer-anchored mononuclear and binuclear CuII Schiff-base complexes: Impact of heterogenization on liquid phase catalytic oxidation of a series of alkenes

Liquid phase catalytic oxidation of a number of alkenes, for example, cyclohexene, cis-cyclooctene, styrene, 1-methyl cyclohexene and 1-hexene, was performed using polymer-anchored copper (II) complexes PS-[Cu (sal-sch)Cl] (5), PS-[Cu (sal-tch)Cl] (6), PS-[CH2{Cu (sal-sch)Cl}2] (7) and PS-[CH2{Cu (sal-tch)Cl}2] (8). Neat complexes [Cu (sal-sch)Cl] (1), [Cu (sal-tch)Cl] (2), [CH2{Cu (sal-sch)Cl}2] (3) and [CH2{Cu (sal-tch)Cl}2] (4) were isolated by reacting CuCl2·2H2O with [Hsal-sch] (I), [Hsal-tch] (II), [H2bissal-sch] (III) and [H2bissal-tch] (IV), respectively, in refluxing methanol. Complexes 1–4 have been covalently anchored in Merrifield resin through the amine nitrogen of the semicarbazide or thiosemicarbazide moiety. A number of analytical, spectroscopic and thermal techniques, such as CHNS analysis, Fourier transform-infrared, UV–Vis, PMR, 13C-NMR, electron paramagnetic resonance, scanning electron microscopy, energy-dispersive X-ray analysis, thermogravimetric analysis, atomic force microscopy, atomic absorption spectroscopy, and electrospray ionization-mass spectrometry, were used to analyze and establish the molecular structure of the ligands (I)–(IV) and complexes (1)–(8) in solid state as well as in solution state. Grafted complexes 5–8 were employed as active catalysts for the oxidation of a series of alkenes in the presence of hydrogen peroxide. Copper hydroperoxo species ([CuIII (sal-sch)-O-O-H]), which is believed to be the active intermediate, generated during the catalytic oxidation of alkenes, are identified. It was found that supported catalysts are very economical, green and efficient in contrast to their neat complexes as well as most of the recently reported heterogeneous catalysts.

Boronic acid-catalyzed selective oxidation of 1,2-diols to α-hydroxy ketones in water

The activation of 1,2-diols through formation of boronate esters was found to enhance the selective oxidation of 1,2-diols to their corresponding α-hydroxy ketones in aqueous medium. The oxidation step was accomplished using dibromoisocyanuric acid (DBI) as a terminal chemical oxidant or an electrochemical process. The electrochemical process was based on the use of platinum electrodes, methylboronic acid [MeB(OH)2] as a catalyst and bromide ion as a mediator. Electro-generated OH- ions (EGB) at the cathode acted as a base and "Br+" ion generated at the anode acted as an oxidant. Various cyclic and acyclic 1,2-diols as substrates were selectively oxidized to the corresponding α-hydroxy ketones via their boronate esters by the two oxidative methods in good to excellent yields.