496042-83-2

Upstream product

• 54105-78-1 1-[(tetrahydro-2H-pyran-2-yl)oxy]-3-methyl-2-butene 
• 556-82-1 3-methyl-2-buten-1-ol 
• 156835-27-7 (E)-1-[(tetrahydro-2H-pyran-2-yl)oxy]-3-methyl-2-buten-4-ol 
• 344558-09-4 (E)-4-(4'-benzoylbenzyloxy)-1-[(tetrahydro-2H-pyran-2-yl)oxy]-3-methyl-2-butene 
• 344558-10-7 (E)-4-(4'-benzoylbenzyloxy)-3-methyl-2-buten-1-ol 

Downstream Products

• 496042-85-4 (E,E)-[4-(5'-phosphono-2'-methyl-2',4'-pentadienyloxymethyl)-phenyl]-phenyl-methanone 
• 793663-39-5 (E,E)-[4-(5'-pyrophosphono-2'-methyl-2',4'-pentadienyloxymethyl)-phenyl]-phenyl-methanone 

Relevant academic research and scientific papers

Phosphonates useful as modulators of t γ(g)9γ(d)2 lymphocyte activity

The invention concerns novel phosphonate derivatives, preparation method, use thereof as ligands modulating T γ9δ2 lymphocyte activity and pharmaceutical compositions comprising them.

Synthesis of vinyl pyrophosphonate analogues of farnesyl pyrophosphate: New potential inhibitors of farnesyl protein transferase

The synthesis of new bioisosteric analogues of farnesyl pyrophosphate where a vinyl pyrophosphonate replaced the pyrophosphate moiety is described. These compounds have been prepared using a Horner-Wadsworth-Emmons procedure and a modified Michelson react