496048-85-2

Upstream product

• 496048-62-5 (2S,4R)-4-benzoyloxy-2-(4-ethoxycarbonylthiazol-2-yl)-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 
• 496048-63-6 (2S,4R)-2-(4-ethoxycarbonylthiazol-2-yl)-4-mesyloxy-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 
• 117333-95-6 (2S,4R)-2-(4-hydroxymethylthiazol-2-yl)-4-mesyloxy-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 
• 496048-61-4 (2S,4R)-4-benzoyloxy-2-thiocarbamoyl-1-(p-nitrobenzyloxycarbonyl)pyrrolidine 
• 117333-96-7 (2S,4S)-4-acetylthio-2-(4-hydroxymethylthiazol-2-yl)-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of 1β-methyl-2-(5-substituted thiazolo pyrrolidin-3-ylthio)carbapenem derivatives

The synthesis of a new series of 1β-methylcarbapenems having the substituted thiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive including MRSA and Gram-negative bacteria were tested and the effect of substituent on the thiazole ring was investigated. A particular compound (28c) having 4′-amide substituted thiazole moiety showed the most potent antibacterial activity.