49615-40-9

Basic information

• Product Name: 3-[(4-AMino-5-pyriMidinyl)Methyl]-5-(2-hydroxyethyl)-4-Methyl-2(3H)-thiazolethione
• Synonyms: 3-[(4-AMino-5-pyriMidinyl)Methyl]-5-(2-hydroxyethyl)-4-Methyl-2(3H)-thiazolethione
• CAS NO: 49615-40-9
• Molecular Formula: C11H14N4OS2
• Molecular Weight: 282.38506
• Mol File: 49615-40-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3-[(4-AMino-5-pyriMidinyl)Methyl]-5-(2-hydroxyethyl)-4-Methyl-2(3H)-thiazolethione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(4-AMino-5-pyriMidinyl)Methyl]-5-(2-hydroxyethyl)-4-Methyl-2(3H)-thiazolethione(49615-40-9)
• EPA Substance Registry System: 3-[(4-AMino-5-pyriMidinyl)Methyl]-5-(2-hydroxyethyl)-4-Methyl-2(3H)-thiazolethione(49615-40-9)

Safety Data

• Hazardous Substances Data: 49615-40-9(Hazardous Substances Data)

Usage

Uses

3-[(4-Amino-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-2(3H)-thiazolethione is an intermediate in the synthesis of Thiamine (T344185) analogues.

Upstream product

• 4786-51-0 3-aminopyrazine-2-carboxamide 

Relevant articles and documents

3 - [(4 - amino -5 - pyrimidinyl) methyl] -5 - (2 - hydroxy ethyl) -4 - methyl thiazole nitrate preparation method

The invention discloses a preparation method for 3-[(4-amino-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazole nitrate. The method comprises the following steps: contacting liquid sodium alkoxide with formamidine hydrochloride and then contacting an obtained substance with a compound represented by a formula (1) so as to obtain 4-amino-5-formylaminomethylpyrimidine; contacting 4-amino-5-formylaminomethylpyrimidine with an alkaline aqueous solution and then contacting an obtained substance with carbon disulfide and gamma-chloroacetyl propanol so as to obtain a compound represented by a formula (2); contacting an acidic aqueous solution with the compound represented by the formula (2) so as to obtain a compound represented by a formula (3); and contacting the compound represented by the formula (3) with hydrogen peroxide, then contacting an obtained substance with nitrate, carrying out neutralization with alkali and then carrying out solid-liquid separation so as to obtain 3-[(4-amino-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazole nitrate. With 3-[(4-amino-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazole nitrate prepared in the invention, accurate qualitative and quantitative analysis of demethylated thiamine can be realized.