49640-97-3

Upstream product

• 762-04-9 phosphonic acid diethyl ester 
• 591-31-1 3-methoxy-benzaldehyde 
• 762-04-9 Diethyl phosphonate 

Downstream Products

• 1237539-48-8 C₁₂H₁₈ClO₄P 
• 1237539-53-5 diethyl α,α-chlorofluoro-3-methoxybenzylphosphonate 
• 1326345-11-2 diethyl α-bromo-3-methoxybenzylphosphonate 
• 1326345-22-5 diethyl α,α-bromofluoro-3-methoxybenzylphosphonate 

Relevant academic research and scientific papers

Surface-mediated solid phase reactions: Preparation of diethyl 1-hydroxyarylmethylphosphonates on the surface of magnesia

Magnesia is found to be an effective catalyst for synthesis of diethyl 1-hydroxyarylmethylphosphonates from aromatic aldehydes and diethyl hydrogen phosphite.

Syntheses of bimetallic rare-earth bis(cyclopentadienyl) derivatives supported by bridged bis(guanidinate) ligands and their catalytic property for the hydrophosphonylation of aldehydes

Some bimetallic rare earth bis(cyclopentadienyl) derivatives supported by bridged bis(guanidinate) ligands {(C5H5)2RE[(RN)2CN(CH2)2]}2 [R = iPr, RE = Yb(1), Er(2), Y(3

Syntheses of bimetallic lanthanide bis(amido) complexes stabilized by bridged bis(guanidinate) ligands and their catalytic activity toward the hydrophosphonylation reaction of aldehydes and ketones

A series of bimetallic lanthanide bis(amido) complexes stabilized by bridged bis(guanidinate) ligands {[(Me3Si)2N]2Ln[(RN)2-CN(CH2)2]}2 [R= i Pr, Ln=Sm (1), Yb (2), Y

N -BuLi as a highly efficient precatalyst for hydrophosphonylation of aldehydes and unactivated ketones

It was found for the first time that organic alkali metal compounds serve as highly efficient precatalysts for the hydrophosphonylation reactions of aldehydes and unactivated ketones with dialkyl phosphite under mild conditions. For ketone substrates, a reversible reaction was observed, and the influence of catalyst loading and reaction temperature on the reaction equilibrium was studied in detail. Overall, the hydrophosphonylation reactions catalyzed by 0.1 mol % n-BuLi were completed within 5 min for a broad range of substrates and generated a series of α-hydroxy phosphonates in high yields.

Lanthanide anilido complexes: Synthesis, characterization, and use as highly efficient catalysts for hydrophosphonylation of aldehydes and unactivated ketones

Lanthanide anilido complexes stabilized by the 2,6-diisopropylanilido ligand have been synthesized and characterized, and their catalytic activity for hydrophosphonylation reaction was explored. A reaction of anhydrous LnCl 3 with 5 equivalents

Synthesis and characterization of amidate rare-earth metal amides and their catalytic activities toward hydrophosphonylation of aldehydes and unactivated ketones

Two novel amidate rare-earth metal amides Ln[N(SiMe3)2](κ2-L1)2(THF) (L1 = C6H5C(O)NC6H3(iPr)2) (Ln = Yb (1), Y (2)) were p

Magnetic Fe3O4 nanoparticle-supported phosphotungstic acid as a recyclable catalyst for the kabachnik-fields reaction of isatins, imines, and aldehydes under solvent-free conditions

Magnetic-nanoparticle-supported phosphotungstic acid has been used to efficiently catalyze the hydrophosphonylation reaction of isatins, imines, and aldehydes using dimethyl and diethyl phosphite as a nucleophile to give the corresponding α-hydroxy and α-amino phosphonates in excellent yields for a wide range of substrates. The reaction conditions were simple, green, and efficient. The catalyst was recycled up to five times with retention of its activity. Based on the NMR spectroscopy studies, a probable catalytic cycle was proposed.

Enantioselective acylphosphonylation-dual lewis acid-lewis base activation of aldehyde and acylphosphonate

Acetoxyphosphonates were obtained by a one-step procedure consisting of reaction of diethyl acetylphosphonate with prochiral aldehydes in the presence of a catalytic system comprising a chiral Lewis acid, an achiral Lewis base, and a Br?nstedt base. Best

N-heterocyclic carbenes catalyzed phospho-aldol reaction of aldehydes

An efficient phospho-aldol reaction of aldehydes catalyzed by N-heterocyclic carbenes (NHCs) has been developed. With 10 mol% stable NHC 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene, various aldehydes reacted with dialkylphosphites smoothly to provide α-hydroxy phosphonates in 59% -99% yield. In this process, NHC was assumed to function as a carbon-centered bronsted base. Copyright

E-Factor minimized hydrophosphonylation of aldehydes catalyzed by polystyryl-BEMP under solvent-free conditions

An efficient protocol for the hydrophosphonylation of aromatic and aliphatic aldehydes catalyzed by PS-BEMP under solvent-free conditions (SolFC) has been reported. Addition reactions were performed by using equimolar amounts of reagents and the resulting