49644-02-2Relevant academic research and scientific papers
Microbiological Transformations Part 7. Microbiological Transformations of A-nor- and A-homo-5α-androstane derivatives with the fungus Cunninghamella elegans.
Crabb, Trevor A.,Ratcliffe, Norman M.
, p. 650 - 669 (2007/10/02)
The microbiological transformation of 17β-hydroxy-A-nor-5α-androstan-2-one, 17β-hydroxy-A-homo-5α-androstan-3-one and 5α-androstan-3,17-dione, by Cunninghamella elegans is dominated by 9α-hydroxylation whereas 17β-hydroxy-5α-androstan-3-one undergoes predominant 7α-monohydroxylation. 9α-Hydroxy-5α-androstane-3,17-dione and 9α-hydroxy-A-homo-5α-androstane-3,17-dione were synthesised by a sequence involving 11α-hydroxylation of the corresponding 3,17-diones by Aspergillus ochraceous.
