49656-08-8

Upstream product

• 119-52-8 4,4'-dimethoxybenzoin 
• 57-13-6 urea 
• 598-55-0 methyl carbamate 
• 51-79-6 urethane 

Downstream Products

• 951744-64-2 4-(4,5-bis(4-methoxyphenyl)oxazol-2-yl)piperazine 
• 49656-06-6 2-chloro-4,5-bis(4-methoxyphenyl)oxazole 
• 62858-76-8 3-benzyl-4,5-bis-(4-methoxy-phenyl)-3H-oxazol-2-one 

Relevant academic research and scientific papers

UREIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES

This invention relates to a pharmaceutical comprising, as an active ingredient, a ureide derivative represented by formula: or a pharmaceutically acceptable salt thereof. The ureide derivative or a pharmaceutically acceptable salt thereof according to the present invention is useful for relieving pain and treating or preventing neuropathic pain.

OXAZOLE DERIVATIVES AS INHIBITORS OF CYCLOOXYGENASE

A compound of the formula (I): wherein R1 is cycloalkyl, etc; R2 is (lower)alkoxy, etc; R3 is (lower)alkylene, etc; R4 is (lower)alkylene, etc; R5 is hydroxy, etc; X is "0", "S", "SO", or "S02"; Y is "CH" or "N"; n is 0 or 1; or pharmaceutically acceptable salts thereof, which are useful as a medicament

Inhibitor of cox

A compound of the formula (I): wherein R1 is cycloalkyl, etc; R2 is (lower)alkoxy, etc; R3 is (lower)alkylene, etc; R4 is (lower)alkylene, etc; R5 is hydroxy, etc; X is “O”, “S”, “SO”, or “SO2”; Y is “CH” or “N”; n is 0 or 1; or pharmaceutically acceptable salts thereof, which are useful as a medicament.

Condensation Reactions of Aryl Acyloins with Ureas in Ethylene Glycol

4,5-Diaryl-4-imidazolin-2-ones were prepared in good yield by heating aryl acyloins with ureas in ethylene glycol for 0.5-2 hours. 4,4'-Dimethoxybenzoin and 2,2'-pyridoin gave 4-oxazolin-2-one derivatives in addition to 4-imidazolin-2-ones.