49675-68-5Relevant articles and documents
Design and synthesis of novel quinazoline derivatives and their evaluation as PI3Ks inhibitors
El-Said, Omar Maged,Hamed, Mostafa Mohamed,Laufer, Stefan,Abadi, Ashraf Hassan
, p. 1166 - 1172 (2015/02/19)
The aim of this work was to synthesize 4-acetamido-, 4-amino- and 4-oxo-6-substituted aminoquinazolines and to evaluate them as phosphoinositide 3-kinases (PI3Ks) inhibitors. The respective chemotype was designed based on combining the structural features
Polycyclic N-heterocyclic compounds, part 67: Reaction of 6,7-substituted N-(quinazolin-4-yl)amidine derivatives with hydroxylamine hydrochloride: Formation of in vitro inhibitors of pentosidine
Okuda, Kensuke,Muroyama, Hideki,Hirota, Takashi
experimental part, p. 1407 - 1413 (2012/01/05)
Reactions of N-(quinazolin-4-yl)amidines and their amide oximes with hydroxylamine hydrochloride gave cyclization products that were formed by an initial ring cleavage of the pyrimidine component followed by a ring closure formation of 1,2,4-oxadiazole to