49675-75-4

Basic information

• Product Name: 4-Quinazolinamine, 6-nitro-N-phenyl-
• CAS NO: 49675-75-4
• Molecular Formula: C14H10N4O2
• Molecular Weight: 266.259
• Mol File: 49675-75-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-Quinazolinamine, 6-nitro-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Quinazolinamine, 6-nitro-N-phenyl-(49675-75-4)
• EPA Substance Registry System: 4-Quinazolinamine, 6-nitro-N-phenyl-(49675-75-4)

Safety Data

• Hazardous Substances Data: 49675-75-4(Hazardous Substances Data)

Upstream product

• 17420-30-3 5-nitroanthranilonitrile 
• 62-53-3 aniline 
• 39263-34-8 N′-(2-cyano-4-nitrophenyl)-N,N-dimethylformimidamide 
• 19815-16-8 4-chloro-6-nitro-quinazoline 

Relevant articles and documents

Large yellow acid anilinoquinazoline derivatives preparation and anti-tumor application

The invention discloses large yellow acid anilinoquinazoline derivatives preparation and for anti-tumor. In order to parietic acid as a lead compound, is introduced into the 4 - anilinoquinazoline structure, synthesis is contained and 1, 8 - [...] - 9, 10 - anthraquinone - N - (6 - amino - 4 - anilinoquinazoline) - 3 - carboxamides of the compound. Cell test Certificate, the class of compounds of the nasopharyngeal carcinoma cells, breast cancer cells, liver cancer cells and ovarian cancer cells with different degree suppression effect, can be used for anti-tumor pharmaceutical preparation.

Microwave-accelerated Dimroth rearrangement for the synthesis of 4-anilino-6-nitroquinazolines. Application to an efficient synthesis of a microtubule destabilizing agent

A useful and rapid access to 4-anilino-6-nitroquinazolines was investigated in a multi-gram scale via microwave-accelerated condensation and Dimroth rearrangement of the starting anilines with imines obtained by reaction of anthranilonitriles with formamide dimethylacetal. A novel short and efficient route to Azixa (EPi28495, MPC-6827), a microtubule destabilizing agent and apoptosis inducer, was performed with success demonstrating that well controlled parameters offer comfortable using of microwave technology with safe and environmental benefits.

Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy

Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) and as