496788-10-4

Basic information

• Product Name: 3-amino-N-(2-chlorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]thieno[3,2-e]pyridine-2-carboxamide
• Synonyms: 3-amino-N-(2-chlorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]thieno[3,2-e]pyridine-2-carboxamide
• CAS NO: 496788-10-4
• Molecular Formula: C20H20ClN3OS
• Molecular Weight: 385.9103
• Mol File: 496788-10-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 532.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.370±0.06 g/cm3(Predicted)
• PKA: 10.87±0.70(Predicted)
• CAS DataBase Reference: 3-amino-N-(2-chlorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]thieno[3,2-e]pyridine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-N-(2-chlorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]thieno[3,2-e]pyridine-2-carboxamide(496788-10-4)
• EPA Substance Registry System: 3-amino-N-(2-chlorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]thieno[3,2-e]pyridine-2-carboxamide(496788-10-4)

Safety Data

• Hazardous Substances Data: 496788-10-4(Hazardous Substances Data)

Upstream product

• 95-51-2 o-chloroaniline 
• 5439-11-2 2-bromo-N-(2'-chlorophenyl)acetamide 
• 154384-02-8 2-thioxo-1,2,5,6,7,8,9,10-octahydrocycloocta[b]pyridine-3-carbonitrile 
• 502-49-8 cycloactanone 

Relevant articles and documents

Synthesis and antiproliferative activity of 2-chlorophenyl carboxamide thienopyridines

3-Amino-2-arylcarboxamide-thieno[2,3-b]pyridines are a known class of antiproliferative compounds with activity against the phospholipase C enzyme. To further investigate the structure activity relationships of these derivatives a series of analogues were prepared modifying key functional groups. It was determined that modification of the 3-amino and 2-aryl carboxamide functionalities resulted in complete elimination of activity, whilst modification at C-5 allowed compounds of greater activity to be prepared.