496791-37-8 Usage
Description
(S)-6-[(3,5-Dimethyl-1H-pyrazol-4-yl)methyl]-5-[(4-hydroxyisoxazolidin-2-yl)carbonyl]-1-isobutyl-3-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione is a complex organic compound with a unique molecular structure. It is characterized by its thieno[2,3-d]pyrimidine core, which is substituted with various functional groups, including a 3,5-dimethyl-1H-pyrazol-4-ylmethyl group, a 4-hydroxyisoxazolidin-2-ylcarbonyl group, an isobutyl group, and a methyl group. (S)-6-[(3,5-Dimethyl-1H-pyrazol-4-yl)methyl]-5-[(4-hydroxyisoxazolidin-2-yl)carbonyl]-1-isobutyl-3-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione exhibits a range of biological activities and potential applications across different industries.
Uses
Used in Pharmaceutical Industry:
(S)-6-[(3,5-Dimethyl-1H-pyrazol-4-yl)methyl]-5-[(4-hydroxyisoxazolidin-2-yl)carbonyl]-1-isobutyl-3-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione is used as a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 for the development of novel therapeutic agents. Its ability to bind to an intracellular site involving transmembrane helices 7-10 makes it a valuable candidate for targeting these transporters, which play a crucial role in various diseases and conditions.
Used in Drug Delivery Systems:
In the field of drug delivery, this compound can be employed to improve the bioavailability and therapeutic outcomes of various drugs. By incorporating it into novel drug delivery systems, such as organic and metallic nanoparticles, its delivery and efficacy against specific targets can be enhanced, potentially leading to more effective treatments for a range of diseases.
Used in Chemical Research:
(S)-6-[(3,5-Dimethyl-1H-pyrazol-4-yl)methyl]-5-[(4-hydroxyisoxazolidin-2-yl)carbonyl]-1-isobutyl-3-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione can also be utilized in chemical research for the synthesis of new compounds and the exploration of novel chemical reactions. Its unique structure and functional groups make it an interesting starting point for the development of new molecules with potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 496791-37-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,9,6,7,9 and 1 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 496791-37:
(8*4)+(7*9)+(6*6)+(5*7)+(4*9)+(3*1)+(2*3)+(1*7)=218
218 % 10 = 8
So 496791-37-8 is a valid CAS Registry Number.
496791-37-8Relevant articles and documents
Optimization of monocarboxylate transporter 1 blockers through analysis and modulation of atropisomer interconversion properties
Guile, Simon D.,Bantick, John R.,Cooper, Martin E.,Donald, David K.,Eyssade, Christine,Ingall, Anthony H.,Lewis, Richard J.,Martin, Barrie P.,Mohammed, Rukhsana T.,Potter, Timothy J.,Reynolds, Rachel H.,St-Gallay, Stephen A.,Wright, Andrew D.
, p. 254 - 263 (2007)
We have previously described a novel series of potent blockers of the monocarboxylate transporter, MCT1, which show potent immunomodulatory activity in an assay measuring inhibition of PMA/ionomycin-induced human PBMC proliferation. However, the preferred
