4968-90-5Relevant academic research and scientific papers
Azabicyclic indole esters as potent 5-HT4 receptor antagonists
Wyman, Paul A.,Gaster, Laramie M.,King, Frank D.,Sutton, Jonathon M.,Ellis, Elizabeth S.,Wardle, Kay A.,Young, Timothy J.
, p. 255 - 261 (2007/10/03)
The synthesis of a series of azabicyclic indole esters is described and their potency reported as 5-HT4 receptor antagonists. Optimization of the most potent compound (19) by preparing the corresponding oxazino[3,2-a]indole ester afforded 34, which had a pIC50 of 9.5 in the guinea pig distal colon longitudinal muscle myenteric plexus preparation.
